Anti-Obesity Effects of the Flower of Prunus persica in High-Fat Diet-Induced Obese Mice

Nutrients. 2019 Sep 11;11(9):2176. doi: 10.3390/nu11092176.


Prunus persica (L.) Batsch is a deciduous fruit tree cultivated worldwide. The flower of P. persica (PPF), commonly called the peach blossom, is currently consumed as a tea for weight loss in East Asia; however, its anti-obesity effects have yet to be demonstrated in vitro or in vivo. Since PPF is rich in phytochemicals with anti-obesity properties, we aimed to investigate the effects of PPF on obesity and its underlying mechanism using a diet-induced obesity model. Male C57BL/6 mice were fed either normal diet, high-fat diet (HFD), or HFD containing 0.2% or 0.6% PPF water extract for 8 weeks. PPF significantly reduced body weight, abdominal fat mass, serum glucose, alanine transaminase and aspartate aminotransferase levels, and liver and spleen weights compared to the HFD control group. Real-time quantitative polymerase chain reaction analysis revealed that PPF suppressed lipogenic gene expression, including stearoyl-CoA desaturase-1 and -2 and fatty acid synthase, and up-regulated the fatty acid β-oxidation gene, carnitine palmitoyltransferase-1, in the liver. Our results suggest that PPF exerts anti-obesity effects in obese mice and these beneficial effects might be mediated through improved hepatic lipid metabolism by reducing lipogenesis and increasing fatty acid oxidation.

Keywords: Prunus persica; anti-obesity; glucose; high-fat diet; lipogenesis; liver; peach blossom; β-oxidation.

MeSH terms

  • Animals
  • Anti-Obesity Agents / isolation & purification
  • Anti-Obesity Agents / pharmacology*
  • Biomarkers / blood
  • Diet, High-Fat
  • Disease Models, Animal
  • Eating
  • Fatty Acids / metabolism*
  • Flowers / chemistry*
  • Gene Expression Regulation
  • Lipogenesis / drug effects*
  • Lipogenesis / genetics
  • Liver / drug effects*
  • Liver / enzymology
  • Male
  • Mice, Inbred C57BL
  • Obesity / blood
  • Obesity / genetics
  • Obesity / physiopathology
  • Obesity / prevention & control*
  • Organ Size
  • Oxidation-Reduction
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology*
  • Prunus persica / chemistry*
  • Weight Loss / drug effects*


  • Anti-Obesity Agents
  • Biomarkers
  • Fatty Acids
  • Plant Extracts