Early Recognition of Persistent Acute Kidney Injury

Semin Nephrol. 2019 Sep;39(5):431-441. doi: 10.1016/j.semnephrol.2019.06.003.


Despite the vast amount of literature dedicated to acute kidney injury (AKI) and its clinical consequences, short-term renal recovery has been relatively neglected. Recent studies have suggested that timing of renal recovery is associated with longer-term risk of death, residual renal function, and end-stage renal failure risk. In addition, longer AKI duration is associated with an increased requirement for renal replacement therapy. Comorbidities, especially renal and cardiovascular, severity of AKI, criteria to reach AKI diagnosis, as well as severity of critical illness have been associated with longer AKI duration, and, more specifically, risk of persistent renal dysfunction. Because predicting short-term renal recovery is clinically relevant, several tests, imaging, and biomarkers have been tested in a way to predict the course of AKI and chances for early renal recovery. In this review, the definition of recovery, consequences of persistent AKI, and tools proposed to predict recovery are described. The performance of these tools and their limits are discussed.

Keywords: Acute kidney injury; Doppler; biomarkers; renal replacement therapy; resistive index; sensitivity; specificity.

Publication types

  • Review

MeSH terms

  • Acute Kidney Injury / diagnosis*
  • Acute Kidney Injury / physiopathology
  • Acute Kidney Injury / therapy
  • Biomarkers / analysis
  • Early Diagnosis
  • Humans
  • Models, Statistical
  • Recovery of Function
  • Ultrasonography, Doppler


  • Biomarkers