Pediatric heart transplant from an incompletely treated influenza A-positive donor

Pediatr Transplant. 2019 Dec;23(8):e13585. doi: 10.1111/petr.13585. Epub 2019 Sep 12.

Abstract

There is a shortage of pediatric donor hearts for waitlisted children, and yet nearly 50% of organs offered are not transplanted. Donor quality is often cited as a reason for declining organs offered from donors infected with influenza, presumably due to concern about disease transmission at transplant leading to severe disease. We previously described an excellent outcome after heart transplant from a donor infected with influenza B that had been treated with a complete course of oseltamivir. In this report, we describe a similar outcome after transplantation of an organ from an influenza A-positive donor with symptomatic disease incompletely treated with oseltamivir. Due to the availability of effective antiviral treatment, we suggest that influenza A is also a manageable donor infection that need not preclude heart placement.

Keywords: heart transplant; influenza; oseltamivir; pediatric.

Publication types

  • Case Reports

MeSH terms

  • Antiviral Agents / therapeutic use
  • Donor Selection*
  • Heart Transplantation*
  • Humans
  • Infant
  • Influenza A virus*
  • Influenza, Human* / drug therapy
  • Male
  • Oseltamivir / therapeutic use

Substances

  • Antiviral Agents
  • Oseltamivir