Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, e12920
[Online ahead of print]

A Brief Period of Sleep Deprivation Leads to Subtle Changes in Mouse Gut Microbiota


A Brief Period of Sleep Deprivation Leads to Subtle Changes in Mouse Gut Microbiota

Sahar El Aidy et al. J Sleep Res.


Not getting enough sleep is a common problem in our society and contributes to numerous health problems, including high blood pressure, diabetes and obesity. Related to these observations, a wealth of studies has underscored the negative impact of both acute and chronic sleep deprivation on cognitive function. More recently it has become apparent that the gut microbiota composition can be rapidly altered, modulates brain function and is affected by the aforementioned health problems. As such, changes in the microbiota composition may contribute to the behavioural and physiological phenotypes associated with sleep deprivation. It is unclear, however, whether a brief period of sleep deprivation can also negatively impact the gut microbiota. Here, we examined the impact of 5 hr of sleep deprivation on gut microbiota composition of male C57Bl6/J mice. Despite the fact that the overall microbial composition did not change between the control- and sleep-deprived groups, the relative abundance of the Clostridiaceae and Lachnospiraceae were slightly altered in sleep-deprived animals compared to controls. Together, these data suggest that depriving mice of sleep for 5 hr leads to subtle changes in the gut microbiota composition.

Keywords: gut; mice; microbiome; microbiota; sleep; sleep deprivation.

Similar articles

See all similar articles



    1. Abel, T., Havekes, R., Saletin, J. M., & Walker, M. P. (2013). Sleep, plasticity and memory from molecules to whole-brain networks. Current Biology, 23, R774-R788.
    1. Anderson, J. R., Carroll, I., Azcarate-Peril, M. A., Rochette, A. D., Heinberg, L. J., Peat, C., … Gunstad, J. (2017). A preliminary examination of gut microbiota, sleep, and cognitive flexibility in healthy older adults. Sleep Medicine, 38, 104-107.
    1. Benedict, C., Vogel, H., Jonas, W., Woting, A., Blaut, M., Schurmann, A., & Cedernaes, J. (2016). Gut microbiota and glucometabolic alterations in response to recurrent partial sleep deprivation in normal-weight young individuals. Molecular Metabolism, 5, 1175-1186.
    1. Bjorness, T. E., Riley, B. T., Tysor, M. K., & Poe, G. R. (2005). REM restriction persistently alters strategy used to solve a spatial task. Learning and Memory, 12, 352-359.
    1. van der Borght, K., Ferrari, F., Klauke, K., Roman, V., Havekes, R., Sgoifo, A., … Meerlo, P. (2006). Hippocampal cell proliferation across the day: Increase by running wheel activity, but no effect of sleep and wakefulness. Behavioral Brain Research, 167, 36-41.

LinkOut - more resources