MRI features associated with high likelihood of conversion of radiologically isolated syndrome to multiple sclerosis

Mult Scler Relat Disord. 2019 Nov;36:101381. doi: 10.1016/j.msard.2019.101381. Epub 2019 Sep 2.


Radiologically isolated syndrome (RIS) is the asymptomatic precursor to clinically isolated syndrome, relapsing-remitting multiple sclerosis (MS) or primary progressive MS. RIS is frequently diagnosed when an individual gets an MRI for an unrelated medical issue, such as headache or trauma. Treating RIS patients is controversial, but physicians may be inclined to offer prophylactic treatment for high-risk RIS patients. Identifying imaging and clinical features associated with high likelihood of early clinical conversion may prove helpful to identify a high-risk subset for potential MS therapy. The goal of this paper is to review current literatures to identify imaging and clinical features that predict early (within 5 years) conversion from RIS to MS.

Keywords: Brain T2 lesions; Brain atrophy; Clinically isolated syndrome; Contrast-enhancement; Relapsing-remitting MS; Spinal cord lesions.

Publication types

  • Review

MeSH terms

  • Brain / diagnostic imaging*
  • Brain / pathology
  • Disease Progression*
  • Humans
  • Magnetic Resonance Imaging*
  • Multiple Sclerosis / diagnostic imaging*
  • Multiple Sclerosis / pathology
  • Spinal Cord / diagnostic imaging*
  • Spinal Cord / pathology