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Review
. 2019 Sep 14.
doi: 10.1002/jmri.26908. Online ahead of print.

Diffusion MRI of the Breast: Current Status and Future Directions

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Review

Diffusion MRI of the Breast: Current Status and Future Directions

Mami Iima et al. J Magn Reson Imaging. .

Abstract

Diffusion-weighted imaging (DWI) is increasingly being incorporated into routine breast MRI protocols in many institutions worldwide, and there are abundant breast DWI indications ranging from lesion detection and distinguishing malignant from benign tumors to assessing prognostic biomarkers of breast cancer and predicting treatment response. DWI has the potential to serve as a noncontrast MR screening method. Beyond apparent diffusion coefficient (ADC) mapping, which is a commonly used quantitative DWI measure, advanced DWI models such as intravoxel incoherent motion (IVIM), non-Gaussian diffusion MRI, and diffusion tensor imaging (DTI) are extensively exploited in this field, allowing the characterization of tissue perfusion and architecture and improving diagnostic accuracy without the use of contrast agents. This review will give a summary of the clinical literature along with future directions. Level of Evidence: 5 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019.

Keywords: ADC; breast diffusion-weighted MRI; diffusion tensor imaging; diffusion time; intravoxel incoherent motion; non-Gaussian diffusion.

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References

    1. Dorrius MD, Dijkstra H, Oudkerk M, Sijens PE. Effect of b value and pre-admission of contrast on diagnostic accuracy of 1.5-T breast DWI: A systematic review and meta-analysis. Eur Radiol 2014;24:2835-2847.
    1. Shi R-y, Yao Q-y, Wu L-m, Xu J-r. Breast lesions: Diagnosis using diffusion weighted imaging at 1.5T and 3.0T-Systematic review and meta-analysis. Clin Breast Cancer 2018;18:e305-e320.
    1. Chen X, Li WL, Zhang YL, Wu Q, Guo YM, Bai ZL. Meta-analysis of quantitative diffusion-weighted MR imaging in the differential diagnosis of breast lesions. BMC Cancer 2010;10:693.
    1. Horvat JV, Bernard-Davila B, Helbich TH, et al. Diffusion-weighted imaging (DWI) with apparent diffusion coefficient (ADC) mapping as a quantitative imaging biomarker for prediction of immunohistochemical receptor status, proliferation rate, and molecular subtypes of breast cancer. J Magn Reson Imaging 2019 [Epub ahead of print].
    1. Suo S, Zhang D, Cheng F, et al. Added value of mean and entropy of apparent diffusion coefficient values for evaluating histologic phenotypes of invasive ductal breast cancer with MR imaging. Eur Radiol 2019;29:1425-1434.

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