Association between Km1 immunoglobulin allotype and pulmonary tuberculosis in Indonesians

Exp Clin Immunogenet. 1987;4(3):129-35.

Abstract

Allotypes were determined in 121 cases of smear-positive pulmonary tuberculosis and 33 healthy controls from Indonesia. It was found that the occurrence of Km1 was significantly lower in patients than in controls (p = 0.011), and that phenotypes lacking G1m (17) and G3m(21) as well as Km1 occurred much more frequently among patients than controls (p = 0.0025). Some evidence for an allotypic influence on the antibody response to mycobacterial antigens was found. A lack of G1m(17) or G3m(21) was associated with increased antibody levels in the IgG2 subclass in control subjects and a lack of Km1 with decreased antibody levels in the IgG4 subclass in patients.

MeSH terms

  • Antibodies, Bacterial / analysis
  • Female
  • Humans
  • Immunoglobulin Allotypes / analysis*
  • Immunoglobulin Gm Allotypes / analysis
  • Indonesia
  • Male
  • Mycobacterium tuberculosis / immunology
  • Tuberculosis, Pulmonary / immunology*

Substances

  • Antibodies, Bacterial
  • Immunoglobulin Allotypes
  • Immunoglobulin Gm Allotypes