Proof of concept of plasmonic thermal destruction of surface cancers by gold nanoparticles obtained by green chemistry

Colloids Surf B Biointerfaces. 2019 Dec 1;184:110496. doi: 10.1016/j.colsurfb.2019.110496. Epub 2019 Sep 8.


A greener approach for the design of surface plasmon resonant gold nanoparticles has been obtained with a hydrosoluble fraction of an endemic asteraceae medicinal plant. This medicinal plant is originated from Indian Ocean and demonstrates its bioreducing activity in the design of stable green nanomedicine in aqueous media. This article describes the preclinical assessment of the efficacy of these novel nanocandidates on murine model by intratumoral and intravenous injections. It definitely demonstrates two key points in the treatment of cancer: 1) optimization of the tumor microenvironment targeting by specific ligands for a limited damage on healthy tissue, 2) the need to screen the specific irradiation dose (time, power) taking into account the type of tumor.

Keywords: Gold nanoparticle; Green nanomedicine; Hyperthermia; Medicinal plant; Plasmonic photothermal therapy.

MeSH terms

  • Animals
  • Apoptosis / drug effects
  • Apoptosis / radiation effects
  • Asteraceae / chemistry
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Cell Survival / radiation effects
  • Gold / administration & dosage
  • Gold / chemistry*
  • Gold / pharmacokinetics
  • Green Chemistry Technology / methods*
  • Humans
  • Injections, Intralesional
  • Injections, Intravenous
  • Light
  • Metal Nanoparticles / administration & dosage
  • Metal Nanoparticles / chemistry*
  • Mice
  • Nanomedicine / methods
  • Neoplasms, Experimental / metabolism
  • Neoplasms, Experimental / pathology
  • Neoplasms, Experimental / therapy
  • Phototherapy / methods
  • Proof of Concept Study
  • Surface Plasmon Resonance / methods*
  • Tumor Burden / drug effects
  • Tumor Burden / radiation effects


  • Gold