Tenosynovial giant cell tumor in the foot and ankle

Foot Ankle Surg. 2020 Aug;26(6):712-716. doi: 10.1016/j.fas.2019.08.014. Epub 2019 Sep 6.


Background: Tenosynovial giant cell tumor (TSGCT) originates from the synovial cells of the tendon sheath and is the most common soft tissue tumor of the foot and ankle. Due to the lack of clinical data about TSGCT in the foot and ankle, this study was performed with the aim of investigating the clinical characteristics, and surgical outcomes that might predict the likelihood of recurrence.

Methods: Clinical data, obtained from the pathology records and the clinic files, along with the tumor subtype, local recurrence, and patient functional status among 26 cases of TSGCT were evaluated with the mean 73 months follow-up period.

Results: There were 26 patients including 16 males and 10 females with a mean age of 40 years, who underwent surgery. There were 15 localised TSGCT and 11 diffuse TSGCT. The diffuse TSGCT was more likely to be in the hindfoot dorsum (54,5%, 6/11). The localised TSGCT was mostly located in the forefoot (80%, 12/15). The recurrence rate in the diffuse TSGCT was 27,3% (3/11). In the localised TSGCT, recurrence was seen in 6,6% of patients (1/15). The mean AOFAS score was 79.

Conclusion: Diffuse TSGCT is more likely to occur in the hindfoot and localised TSGCT is more common in the forefoot. Excision with clear margins is an effective treatment for TSGCT, with good oncological and clinical outcomes. But the orthopaedic surgeons should consider the equilibrium between surgical margins and the functional status of the patient.

Keywords: Foot and ankle; Giant cell tumor of the tendon sheath; Recurrence; Tenosynovial giant cell tumor.

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Female
  • Foot / surgery*
  • Giant Cell Tumor of Tendon Sheath / pathology*
  • Giant Cell Tumor of Tendon Sheath / surgery*
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local
  • Retrospective Studies
  • Soft Tissue Neoplasms / pathology*
  • Soft Tissue Neoplasms / surgery*
  • Young Adult