TNF induces production of type 2 cytokines in human group 2 innate lymphoid cells

J Allergy Clin Immunol. 2020 Jan;145(1):437-440.e8. doi: 10.1016/j.jaci.2019.09.001. Epub 2019 Sep 14.

Abstract

TNF receptor II is expressed on ILC2s and TNF is able to induce production of type 2 cytokines in human ILC2s. TNF may play a role in causing or amplifying type 2 immunity contributing to health and disease.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Immunity, Innate*
  • Jurkat Cells
  • Lymphocytes / immunology*
  • Receptors, Tumor Necrosis Factor, Type II / immunology*
  • Tumor Necrosis Factors / immunology*

Substances

  • Receptors, Tumor Necrosis Factor, Type II
  • Tumor Necrosis Factors