Evaluation of different platelet-rich concentrates effects on early soft tissue healing and socket preservation after tooth extraction

Abstract

Background: The present study aimed to analyze the early soft tissue healing characteristics and Fractal Dimension (FD) of extraction sockets preserved by Leukocyte-platelet-rich fibrin (L-PRF) and titanium prepared platelet-rich fibrin (T-PRF).

Materials and methods: 57 single-tooth extraction sockets were included in the study, three groups were prepared: post-extraction sockets filled with L-PRF (n=19) and T-PRF (n=19), and control group; naturally healing sockets (n=19). Three months after tooth extraction, FD measurement was made in the center of the healing socket. The Landry Wound Healing Index (LWHI) and H₂O₂ bubbling test results for the complete wound epithelization (CWE) rates were recorded 1 and 2 weeks postoperatively. All patients were asked to record a visual analog scale (VAS) value for pain and the number of analgesics taken during the 3 days after the extraction.

Results: CWE using H₂O₂ test result showed a significantly lower rate in the controls than in L-PRF and T-PRF groups at 1st week. At 2nd weeks, both of the test groups showed 100% CWE compared with only 40.7% in the control group. The VAS pain score was significantly higher in the control group than in L-PRF and T-PRF groups on the 1st day. However, no significant difference was found among the groups on 2nd day. FD value of control group was significantly lower than the L-PRF group and T-PRF group.

Conclusions: T-PRF and L-PRF similarly enhanced wound epithelization and reduced postoperative discomfort at extraction sockets. The T-PRF procedure resulted in higher FD compared to the L-PRF and control group.

Keywords: Extraction; Fractals; Platelet-rich fibrin; Post-extractional healing preservation; Radiography; Socket preservation.