Bacteriophages as Adjuvant to Antibiotics for the Treatment of Periprosthetic Joint Infection Caused by Multidrug-Resistant Pseudomonas aeruginosa

Antimicrob Agents Chemother. 2019 Dec 20;64(1):e00924-19. doi: 10.1128/AAC.00924-19. Print 2019 Dec 20.

Abstract

We documented the adjunctive bacteriophage therapy to treat a chronic relapsing periprosthetic joint infection of the knee and chronic osteomyelitis of the femur caused by multidrug-resistant Pseudomonas aeruginosa The combined antibiotic-phage treatment eradicated the infection, and no side effects to phages were observed.

Keywords: MDR Pseudomonas aeruginosa; bacteriophage therapy; biofilm infections; periprosthetic joint infection.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged, 80 and over
  • Anti-Bacterial Agents / therapeutic use
  • Combined Modality Therapy
  • Device Removal
  • Drug Resistance, Multiple, Bacterial
  • Female
  • Humans
  • Knee Joint
  • Knee Prosthesis / adverse effects
  • Osteomyelitis / drug therapy
  • Osteomyelitis / microbiology
  • Osteomyelitis / therapy
  • Phage Therapy*
  • Prosthesis-Related Infections / drug therapy
  • Prosthesis-Related Infections / microbiology
  • Prosthesis-Related Infections / therapy*
  • Pseudomonas Infections / drug therapy
  • Pseudomonas Infections / microbiology
  • Pseudomonas Infections / therapy*
  • Pseudomonas aeruginosa* / drug effects
  • Recurrence

Substances

  • Anti-Bacterial Agents