A Meta-Analysis on Human Papillomavirus Type Distribution among Women with Cervical Neoplasia in the WHO Eastern Mediterranean Region

Intervirology. 2019;62(3-4):101-111. doi: 10.1159/000502824. Epub 2019 Sep 17.


Introduction: To date, the human papillomavirus (HPV) vaccine has not been integrated into the national vaccination program of most countries of the WHO Eastern Mediterranean Region (EMRO), except for the United Arab Emirates and Libya. The knowledge of HPV genotype distribution in cervical neoplasia is valuable to predict the impact of current HPV vaccines on cancer prevention and can help the health policymakers to select the most appropriate vaccine types in their countries.

Methods: Hence, this meta-analysis recapitulates all available data on HPV prevalence and genotypes in women with atypical squamous cells of undetermined significance (ASCUS), cervical intraepithelial neoplasia (CIN) I-III or low- and high-grade squamous intraepithelial lesions (LSIL and HSIL, respectively), and invasive cervical cancer (ICC) in EMRO countries.

Results: The meta-analysis included 5,990 cases of cervical precancer and cancer. The overall HPV prevalence was 85.4, 71.3, 59.2, and 34.8% in women with ICC, CIN II-III or HSIL, CIN I or LSIL, and ASCUS, respectively. HPV 16 was the most common genotype followed by HPV 18, representing 58 and 16.5% in ICC cases, respectively.

Conclusion: This meta-analysis showed that the introduction of current HPV vaccines into national vaccination programs and the establishment of comprehensive screening programs in EMRO countries is beneficial by preventing 74.5% of cervical neoplasia.

Keywords: Atypical squamous cells of undetermined significance; Cervical cancer; Cervical intraepithelial neoplasia; Eastern Mediterranean Region (EMRO); HPV type; Human papillomavirus; Vaccines.

Publication types

  • Meta-Analysis
  • Systematic Review

MeSH terms

  • Female
  • Genotype*
  • Humans
  • Mediterranean Region / epidemiology
  • Neoplasms, Squamous Cell / epidemiology
  • Neoplasms, Squamous Cell / virology
  • Papillomaviridae / classification*
  • Papillomaviridae / genetics*
  • Papillomaviridae / isolation & purification
  • Papillomavirus Infections / epidemiology*
  • Papillomavirus Infections / virology*
  • Prevalence
  • Uterine Cervical Neoplasms / epidemiology*
  • Uterine Cervical Neoplasms / virology*