Wave of the future: involvement of actin polymerization in the regulation of tissue growth and shape

Jonathan Cohen; Chen Luxenburg

doi:10.1080/23723556.2019.1609877

Wave of the future: involvement of actin polymerization in the regulation of tissue growth and shape

Mol Cell Oncol. 2019 May 29;6(5):e1609877. doi: 10.1080/23723556.2019.1609877. eCollection 2019.

Authors

Jonathan Cohen¹, Chen Luxenburg¹

Affiliation

¹ Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Abstract

The WASP-family verprolin-homologous (Wave) complex enhances actin-related protein 2/3 (Arp2/3)-mediated actin polymerization. Recently, we have identified a novel Wave complex-actin-Wnt/β-catenin-Sox9 pathway that regulates epidermal morphogenesis and proliferation. These findings highlight a mechanism by which actin polymerization impacts crucial signaling events in vivo.

Keywords: SOX9; Wave complex; Wnt; actin polymerization; epidermis.

Grants and funding

This work was supported by grants to C. L. from the Israel Science Foundation (1113/15) and the Israeli Centers for Research Excellence (I-CORE) Gene Regulation in Complex Human Disease (41/11).