Autophagy is a complex degradation pathway responsible for clearing damaged and dysfunctional organelles. High-fat-diet-induced obesity has been shown to alter autophagy throughout the body in a tissue-specific manner. The impact of obesity on skeletal muscle autophagy has yet to be elucidated. This review examines the impact of high-fat-diet-induced obesity and exercise on skeletal muscle autophagy. Better understanding this major quality control mechanism may help develop novel therapies to combat high-fat-diet-induced obesity comorbidities.
Keywords: autophagy; exercise; high-fat diet; obesity; skeletal muscle.
© The Author(s) 2019. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.