Phage Display: Simple Evolution in a Petri Dish (Nobel Lecture)

Angew Chem Int Ed Engl. 2019 Oct 7;58(41):14428-14437. doi: 10.1002/anie.201908308. Epub 2019 Sep 17.

Abstract

Playing with evolution: In his Nobel lecture, George P. Smith reconstructs the story of the phage-display idea as he personally experienced it. The development of this technique is a case study in how a scientific advance emerges gradually in incremental steps within overlapping global scientific communities.

Keywords: Nobel lecture; affinity selection; peptide library; phage display.

Publication types

  • Lecture
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Bacteriophages / genetics*
  • Cell Surface Display Techniques*
  • DNA, Viral
  • Evolution, Molecular*
  • Nobel Prize
  • Peptide Library*

Substances

  • DNA, Viral
  • Peptide Library