Pre-existing medical disorders as risk factors for preeclampsia: an exploratory case-control study

Hypertens Pregnancy. 2019 Nov;38(4):245-251. doi: 10.1080/10641955.2019.1667381. Epub 2019 Sep 18.

Abstract

Objective: We sought to explore pre-existing medical disorders as risk factors for preeclampsia as thoroughly as possible. Methods: A case-control design. A group of 1,652 patients were identified as the preeclampsia group, and another randomly selected 4,500 patients were identified as the non-preeclampsia group. Results: Mature ovarian teratoma (adjusted odds ratio [OR] 7.69, 95% CI 1.58-37.53), uterine fibroids (adjusted OR 2.24, 95% CI 1.28-3.92) and pregestational hypothyroidism (adjusted OR 5.17, 95% CI 2.43-11.00), were significantly correlated with preeclampsia. Conclusions: Mature ovarian teratoma, uterine fibroids and pregestational hypothyroidism may also contribute to the incidence of preeclampsia.

Keywords: Preeclampsia; case-control study; pre-existing medical disorder; risk factors.

MeSH terms

  • Adult
  • Case-Control Studies
  • China / epidemiology
  • Female
  • Humans
  • Hypothyroidism / complications
  • Leiomyoma / complications
  • Ovarian Neoplasms / complications
  • Pre-Eclampsia / epidemiology*
  • Pre-Eclampsia / etiology
  • Pregnancy
  • Risk Factors
  • Teratoma / complications
  • Young Adult