Evaluation of platelet distribution width as a diagnostic and prognostic biomarker in bladder neoplasm

Future Oncol. 2019 Nov;15(33):3797-3807. doi: 10.2217/fon-2019-0441. Epub 2019 Sep 18.

Abstract

Aim: To evaluate the role of preoperative platelet distribution width (PDW) as a potential biomarker for distinguishing malignancy and tumor advantage of bladder neoplasm. Methods: The study included 210 subjects with bladder cancer, 76 subjects with urothelial papilloma and 132 healthy control subjects. Preoperative PDW along with other blood indices was evaluated. Results: PDW was higher in urothelial papilloma patients than that in bladder cancer patients (p < 0.001). Bladder cancer patients with advanced-stage disease exhibited lower PDW levels compared with patients with early stage disease. Conclusion: Reduced preoperative PDW level is an indicator of malignancy and advanced bladder cancer stages, suggesting it as a potential biomarker in bladder cancer diagnosis and prognosis.

Keywords: TNM stage; bladder cancer; platelet distribution width; urothelial papilloma.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor / blood*
  • Cystectomy
  • Disease-Free Survival
  • Female
  • Humans
  • Kaplan-Meier Estimate
  • Male
  • Mean Platelet Volume*
  • Middle Aged
  • Neoplasm Staging
  • Papilloma / blood
  • Papilloma / diagnosis
  • Papilloma / mortality
  • Papilloma / surgery
  • Preoperative Period
  • Prognosis
  • Retrospective Studies
  • Survival Rate
  • Urinary Bladder / pathology*
  • Urinary Bladder / surgery
  • Urinary Bladder Neoplasms / blood
  • Urinary Bladder Neoplasms / diagnosis*
  • Urinary Bladder Neoplasms / mortality
  • Urinary Bladder Neoplasms / surgery
  • Urothelium / pathology*
  • Young Adult

Substances

  • Biomarkers, Tumor