Childhood cancer in siblings

Pediatr Hematol Oncol. 1986;3(3):229-39. doi: 10.3109/08880018609031222.


The medical records of 973 previously untreated patients diagnosed between January 1960 and December 31, 1978 with childhood cancer were reviewed. Siblings in 13 families were diagnosed with cancer 9/12 to 15 years after the diagnosis of cancer in the index sibling. Previously unreported association of acute lymphoblastic leukemia with Hodgkin's disease, neuroblastoma with malignant hemangiopericytoma, non-Hodgkin's lymphoma with malignant melanoma, Wilms' tumor with non-Hodgkin's lymphoma, Hodgkin's disease with malignant teratoma of the testis and craniopharyngioma with acute myeloblastic leukemia were identified. Two families appeared to transmit a predisposition to childhood tumors. The data from these families extend previous observations regarding multiple cases of cancer in sibships.

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Disease Susceptibility
  • Family*
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Neoplasms / epidemiology
  • Neoplasms / genetics*
  • New York / epidemiology
  • Pedigree