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Anxiety and Depression in Patients With alpha-1 Antitrypsin Deficiency: Current Insights and Impact on Quality of Life


Anxiety and Depression in Patients With alpha-1 Antitrypsin Deficiency: Current Insights and Impact on Quality of Life

Tatsiana Beiko et al. Ther Clin Risk Manag.


Chronic physical illness is associated with significant vulnerability for emotional disorders. Some studies suggest anxiety and depression are common comorbidities in individuals with alpha-1 antitrypsin deficiency (AATD). Many aspects of AATD contribute to quality of life impairment. Delays in diagnosis, high costs of disease treatment, and inherited genetic risk add to the symptom burden of lung or liver disease to alter quality of life. Whether anxiety and depression independently contribute to quality of life impairment remains unproven. In this article, we aim to review current literature examining the impact of anxiety and depression on the quality of life of AATD-affected individuals. Multifaceted approaches may best meet the needs of a heterogeneous population and are the best future strategies to minimize these emotional impacts and assure highest quality of life possible. More research studies are needed to achieve this ambitious goal and make life of AATD-affected individuals better by minimizing the effects of anxiety and depression.

Keywords: alpha-1 antitrypsin deficiency; anxiety; depression.

Conflict of interest statement

Dr Charlie Strange reports grants from Alpha-1 Foundation, during the conduct of the study; grants and personal fees from Grifols, CSL Behring, Vertex and Adverum, outside the submitted work; personal fees from Shire/Takeda, and grants from MatRx, outside the submitted work. The authors report no other conflicts of interest in this work.


Figure 1
Figure 1
The impact of depression and anxiety in COPD. Anxiety and depression often overlap in COPD. This figure aims to show the complex effects of both anxiety and depression on patient-centered outcomes such as dyspnea scores, health status, higher admission rates, and decreased participation in programs aimed at rehabilitation and smoking cessation.

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