Recent advancement of engineering microbial hosts for the biotechnological production of flavonoids

Mol Biol Rep. 2019 Dec;46(6):6647-6659. doi: 10.1007/s11033-019-05066-1. Epub 2019 Sep 18.


Flavonoids are polyphenols that are important organic chemicals in plants. The health benefits of flavonoids that result in high commercial values make them attractive targets for large-scale production through bioengineering. Strategies such as engineering a flavonoid biosynthetic pathway in microbial hosts provide an alternative way to produce these beneficial compounds. Escherichia coli, Saccharomyces cerevisiae and Streptomyces sp. are among the expression systems used to produce recombinant products, as well as for the production of flavonoid compounds through various bioengineering approaches including clustered regularly interspaced short palindromic repeats (CRISPR)-based genome engineering and genetically encoded biosensors to detect flavonoid biosynthesis. In this study, we review the recent advances in engineering model microbial hosts as being the factory to produce targeted flavonoid compounds.

Keywords: Escherichia coli; Flavonoid; Metabolic engineering; Saccharomyces cerevisiae; Streptomyces sp..

Publication types

  • Review

MeSH terms

  • Bacteriological Techniques / methods*
  • Biosynthetic Pathways
  • Clustered Regularly Interspaced Short Palindromic Repeats
  • Escherichia coli / genetics
  • Escherichia coli / growth & development
  • Flavonoids / biosynthesis*
  • Flavonoids / genetics
  • Metabolic Engineering / methods*
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / growth & development
  • Streptomyces / genetics
  • Streptomyces / growth & development


  • Flavonoids