Cleavage of immunoglobulins by pathogenic yeasts of the genus Candida

Microbiol Sci. 1986 Oct;3(10):316-9.


The yeast-like fungi Candida albicans and Candida tropicalis are opportunistic pathogens which are distinguished from less virulent yeasts by the secretion of acid proteases. Candida proteases cleave various human immunoglobulins including IgA2 and secretory immunoglobulins. They cover a wider range of substrates than bacterial IgA-proteases, and possibly play a role in the pathogenesis of thrush and deep candidosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Candida / enzymology*
  • Candidiasis / enzymology*
  • Hydrolysis
  • Peptide Hydrolases / chemistry
  • Peptide Hydrolases / metabolism*
  • Serine Endopeptidases*


  • Peptide Hydrolases
  • Serine Endopeptidases
  • IgA-specific serine endopeptidase