Cardiometabolic risk factors in women with non-classic congenital adrenal hyperplasia

Acta Cardiol. 2020 Dec;75(8):705-710. doi: 10.1080/00015385.2019.1666964. Epub 2019 Sep 20.

Abstract

Background: No previous study has investigated cardiometabolic risk factors in untreated patients with congenital adrenal hyperplasia (CAH).Methods: The study population consisted of 14 premenopausal women with previously untreated non-classic congenital adrenal hyperplasia (NC-CAH) and 20 matched healthy women. Apart from 17-hydroxyprogesterone and androgen levels, the outcomes of interest were glucose homeostasis markers, plasma lipids, plasma levels of uric acid, C-reactive protein, fibrinogen, homocysteine and 25-hydroxyvitamin D, as well as urinary albumin-to-creatinine ratio (UACR).Results: As expected, women with NC-CAH were characterised by higher levels of 17-hydroxyprogesterone and were more insulin-resistant than control women. The mean values of C-reactive protein, fibrinogen, homocysteine and UACR were higher while 25-hydroxyvitamin D levels were lower in subjects with NC-CAH. The investigated cardiometabolic risk factors correlated with androgen levels and insulin sensitivity.Conclusions: The obtained results suggest that the occurrence of NC-CAH in premenopausal women may increase cardiometabolic risk.

Keywords: Adrenal cortex; congenital adrenal hyperplasia; hormones; risk factors.

Publication types

  • Comparative Study

MeSH terms

  • Adrenal Hyperplasia, Congenital / blood
  • Adrenal Hyperplasia, Congenital / epidemiology*
  • Adult
  • Biomarkers / blood
  • C-Reactive Protein / metabolism*
  • Cardiometabolic Risk Factors*
  • Female
  • Humans
  • Incidence
  • Insulin Resistance / physiology*
  • Poland / epidemiology
  • Risk Factors
  • Uric Acid / blood*
  • Young Adult

Substances

  • Biomarkers
  • Uric Acid
  • C-Reactive Protein