Starving the Devourer: Cutting Cancer Off from Its Favorite Foods

William P Katt; Michael J Lukey; Richard A Cerione

doi:10.1016/j.chembiol.2019.09.005

Starving the Devourer: Cutting Cancer Off from Its Favorite Foods

Cell Chem Biol. 2019 Sep 19;26(9):1197-1199. doi: 10.1016/j.chembiol.2019.09.005.

Authors

William P Katt¹, Michael J Lukey¹, Richard A Cerione²

Affiliations

¹ Department of Molecular Medicine, Cornell University, Ithaca, NY 14853, USA.
² Department of Molecular Medicine, Cornell University, Ithaca, NY 14853, USA; Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA. Electronic address: rac1@cornell.edu.

PMID: 31539503
DOI: 10.1016/j.chembiol.2019.09.005

Abstract

Increased consumption of glucose and glutamine are metabolic hallmarks of tumorigenesis. In this issue of Cell Chemical Biology, Reckzeh et al. (2019) describe the discovery of Glutor, a potent inhibitor of cellular glucose uptake. Combining Glutor with the glutaminase inhibitor CB-839 creates a metabolic crisis in cancer cells, synergistically impeding proliferation.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Cell Proliferation
Glucose
Glucose Transport Proteins, Facilitative*
Glutaminase*
Glutamine

Substances

Glucose Transport Proteins, Facilitative
Glutamine
Glutaminase
Glucose

Abstract

Publication types

MeSH terms

Substances

Grants and funding