Dynamic CT myocardial perfusion imaging

J Cardiovasc Comput Tomogr. 2020 Jul-Aug;14(4):303-306. doi: 10.1016/j.jcct.2019.09.003. Epub 2019 Sep 11.


Cardiac CT offers several approaches to establish the hemodynamic severity of coronary artery obstructions. Dynamic myocardial perfusion CT (MPICT) is based on serial CT imaging to measure the inflow of contrast medium into the myocardium and calculate absolute measures of myocardial perfusion. This review describes the MPICT acquisition protocol, post-image acquisition processing and calculation of quantitative parameters, the diagnostic performance of MPICT and the potential incremental value of this technique in comparison to alternative approaches. Further technical innovation using different scanner platforms and establishment of reproducible diagnostic thresholds to differentiate significant coronary artery disease will be crucial in the path to broader clinical implementation.

Keywords: Computed tomography; Coronary artery disease; Myocardial blood flow; Myocardial perfusion imaging.

Publication types

  • Review

MeSH terms

  • Computed Tomography Angiography*
  • Coronary Angiography*
  • Coronary Artery Disease / diagnostic imaging*
  • Coronary Artery Disease / physiopathology
  • Coronary Vessels / diagnostic imaging*
  • Coronary Vessels / physiopathology
  • Fractional Flow Reserve, Myocardial
  • Humans
  • Multidetector Computed Tomography*
  • Myocardial Perfusion Imaging / methods*
  • Predictive Value of Tests
  • Prognosis
  • Reproducibility of Results
  • Severity of Illness Index