Bisphenol A analogs in patients with chronic kidney disease and dialysis therapy

Ecotoxicol Environ Saf. 2019 Dec 15;185:109684. doi: 10.1016/j.ecoenv.2019.109684. Epub 2019 Sep 18.

Abstract

Bisphenol A (BPA) accumulates in patients with chronic kidney disease (CKD), and hemodialysis filters may contribute to bisphenol burden in patients on hemodialysis (HD). The serum levels of BPA and three BPA analogs, namely, bisphenol B (BPB), bisphenol S (BPS), and bisphenol F (BPF), in 58 patients with CKD, 66 patients on dialysis therapy and 30 healthy control were investigated. The content of four bisphenols (BPs) was also examined in three types of dialysis filters, followed by an in vitro elution experiment to test the release of BPs from the dialysis filters. The serum levels of BPA (r = -0.746, p < 0.05) and BPS (r = -0.433, p < 0.05) in 58 CKD patients and 30 healthy control were correlated with the decrease in estimated glomerular filtration rate. The serum levels of BPs in the HD patients were higher than those in the peritoneal dialysis patients (p < 0.05). In the in vitro study on the BP contents in dialysis filters, BPA was the main form of the BPs in the polysulfone membrane (20.86 ± 1.18 ng/mg) and in the polyamide membrane (18.70 ± 2.88 ng/mg), and a modicum of BPS (0.01 ± 0.01 ng/mg) was detected in the polyethersulfone membrane. The results of the elution experiment were in accordance with the results of BPs content in the dialysis filters. Insufficient renal function may lead to BPs accumulation in patients with CKD, and BPs in dialysis products may cause BPs burden in patients on HD.

Keywords: Bisphenols; Chronic kidney disease; Hemodialysis; Human exposure.

MeSH terms

  • Benzhydryl Compounds / blood*
  • Glomerular Filtration Rate
  • Humans
  • Membranes, Artificial
  • Phenols / blood*
  • Polymers / chemistry
  • Renal Dialysis / methods*
  • Renal Insufficiency, Chronic / blood*
  • Renal Insufficiency, Chronic / therapy
  • Sulfones / blood*
  • Sulfones / chemistry

Substances

  • Benzhydryl Compounds
  • Membranes, Artificial
  • Phenols
  • Polymers
  • Sulfones
  • bisphenol F
  • bisphenol B
  • polysulfone P 1700
  • polyether sulfone
  • bis(4-hydroxyphenyl)sulfone
  • bisphenol A