A Systematic Review on Organophosphate Pesticide and Type II Diabetes Mellitus

Curr Diabetes Rev. 2020;16(6):586-597. doi: 10.2174/1573399815666190712192844.


Organophosphate (OP) pesticides are extremely poisonous and they affect the glucose breakdown in numerous and mechanism. There are higher evidence of stimulating diabetes mellitus through OP pesticides especially the type II diabetes. The upsurge in the level of glucose (hyperglycemia), and insulin resistance along with their related outcomes are discussed in this review. The data related to investigational and clinical techniques endorse a connection amid such molecular mechanism and compounds of OPs. Numerous studies conducted till March 2018 have reported OP' exposures and diabetes-related outcomes. The acute and chronic exposure in case of these insecticides and diabetesrelated outcomes are defined in this study. Initially, it was declared that OPs prompt to hyperglycemia. Then, a high association of glucose in blood beside insulin was found out. The affirmation from some clinical as well as investigational studies supported a connection amid exposure to OP and diabetes, yet in maximum number of instances, non-specific diabetes occurs.

Keywords: Diabetes mellitus; glucose metabolism; organophosphates; pesticides; type-II diabetes mellitus..

Publication types

  • Systematic Review

MeSH terms

  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / chemically induced*
  • Diabetes Mellitus, Type 2 / etiology
  • Diabetes Mellitus, Type 2 / physiopathology
  • Humans
  • Hydrocarbons, Chlorinated / adverse effects
  • Hydrocarbons, Chlorinated / pharmacology
  • Hyperglycemia / blood
  • Hyperglycemia / chemically induced
  • Hyperglycemia / etiology
  • Insulin Resistance
  • Lipid Metabolism / drug effects
  • Obesity / chemically induced
  • Organophosphates / adverse effects*
  • Organophosphates / pharmacology
  • Pancreas / drug effects
  • Pesticides / adverse effects*
  • Pesticides / pharmacology


  • Hydrocarbons, Chlorinated
  • Organophosphates
  • Pesticides