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Is There a Link Between Basal Metabolic Rate, Spleen Volume and Hepatic Growth Factor Levels in Patients With Obesity-Related NAFLD?

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Is There a Link Between Basal Metabolic Rate, Spleen Volume and Hepatic Growth Factor Levels in Patients With Obesity-Related NAFLD?

Giovanni Tarantino et al. J Clin Med.

Abstract

Background: Recent pieces of research point to a link between basal metabolic rate (BMR) and non-alcoholic fatty liver disease (NAFLD) or hepatic steatosis (HS). The spleen in obese patients is associated with the cardiovascular system. Enlargement of the spleen is suggestive of nonalcoholic steatohepatitis (NASH). Patients with NASH present an increase in growth factor (HGF) as well as those with advanced heart failure. Interleukin-16 and interleukin-12p40 levels were found to correlate significantly with BMI, and waist circumference.

Aim: We tried to find a relationship between BMR, spleen length and HGF.

Methods: We analysed retrospective data from 80 obese patients with NAFLD. We evaluated indices of indirect calorimetry by the bioimpendance analysis; carotid intima-media thickness (IMT), spleen length (SLD) and HS by ultrasonography; serum HGF, IL-16, IL-12p40 and IL-6 concentrations by a magnetic bead-based multiplex immunoassays and the severity of NAFLD by BARD score > 2.

Results: HGF levels of the obese were higher than those of controls, p < 0.001. At linear regression, BMR was foreseen by spleen length (p < 0.001), which was predicted by HGF (p = 0.04). BMR was predicted by IL-16 (p = 0.005), which predicted HGF, p = 0.034. Only fat mass, among other factors, predicted early atherosclerosis, p = 0.017; IL-12p40 did not predict IMT, HGF and BMR (p = 0.57, 0.09 and 0.59, respectively). The BARD score > 2 was negatively predicted by BMR and FFM (p =0.032 and 0.031, respectively), at the logistic regression. Interesting findings at the extended regression (mediation effect) were: IL-16 was likely causal in predicting BMR by HGF levels; HGF was influential in predicting BMR by SLD level. HS was predicted by SLD in males (p = 0.014), of advanced age (p < 0.001) and by BMR (p < 0.001). IL-6 concentrations, but not BMR were influential in the prediction of HS by SLD.

Conclusion: These data reinforce the concept that the immune system is a sensor of the metabolic state, showing a link between HGF levels and BMR, which is mediated by IL-16 (cytokine inducing a cascade of inflammatory factors), and ascertaining the influential effect of the spleen, as main immune organ.

Keywords: HGF; NAFLD; calorimetry indices; obesity; spleen.

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Growth factor concentrations in the obese and controls. Legend to Figure 1: HGF, hepatic growth factor. It is noteworthy to stress that the outliners were very few and that there is scarce overlapping between groups.
Figure 2
Figure 2
Association between spleen length and severity of hepatic steatosis. Legend to Figure 2: SLD, spleen longitudinal diameter; HS at US, hepatic steatosis at ultrasonography.

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