First report of a successful pediatric heart transplantation from donation after circulatory death with distant procurement using normothermic regional perfusion and cold storage

J Heart Lung Transplant. 2019 Oct;38(10):1112-1115. doi: 10.1016/j.healun.2019.08.009. Epub 2019 Aug 10.


Heart transplantation (HT) from donation after circulatory death (DCD) is a promising alternative to expand the heart donor pool. Cold storage can be used in a strategy to successfully retrieve and transplant DCD hearts after reconditioning using normothermic regional perfusion for distant procurement. Herein, we present the first report of a pediatric DCD heart reconditioned with normothermic regional perfusion, preserved using only cold storage while being transported to a neighboring center, and then successfully transplanted after nearly 2 hours of cold static storage. If supported by an appropriate trial, this finding could obviate the need to use expensive perfusion devices for short interhospital distances for DCD heart transportation and stimulate more centers across the world to embrace DCD HT.

Keywords: cold static storage; donation after circulatory death; heart transplantation; normothermic regional perfusion; organ donation.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Cadaver
  • Child
  • Cold Temperature
  • Heart Transplantation*
  • Humans
  • Male
  • Organ Preservation / methods*
  • Perfusion / methods
  • Tissue Donors
  • Tissue and Organ Procurement / methods*
  • Treatment Outcome