Urinary bisphenol A and serum lipids: a meta-analysis of six NHANES examination cycles (2003-2014)

J Epidemiol Community Health. 2019 Nov;73(11):1012-1019. doi: 10.1136/jech-2019-212555. Epub 2019 Sep 24.


Background: Mounting evidence from both experimental and epidemiological studies suggest that exposure to the endocrine disruptor bisphenol A (BPA) has a role in metabolic disorders. The aim of the present study was to assess whether urinary BPA concentrations were associated with dyslipidaemia in children (≤17 years old) and adults (≥18 years old) by performing a meta-analysis of data from six cycles (2003-2014) in the National Health and Nutrition Examination Survey (NHANES).

Methods: We conducted a meta-analysis of data from 4604 children and 10 989 adult participants who were part of a substudy of urinary BPA measurements from six NHANES cycles from 2003 to 2014. Linear regression models conducted in each cycle were used to perform a meta-analysis to investigate associations between urinary BPA and serum levels of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), triglycerides (TG) and apolipoprotein B (ApoB).

Results: The meta-analysis did not disclose any significant associations between urinary BPA concentrations and LDL-C, HDL-C, TC, TG and ApoB in children. In adults, the meta-analysis revealed negative regression coefficients for all five lipid variables. However, no associations were significant following Bonferroni correction for multiple tests.

Conclusions: In the present meta-analysis of cross-sectional data from NHANES, no associations were found between urinary BPA and the five different lipid variables when investigated in both children and adults. However, considering the cross-sectional nature of the present study, results should be clarified in carefully designed longitudinal cohort studies with repeated BPA measurements.

Keywords: NHANES; bisphenol A (BPA; epidemiology; lipid levels; meta-analysis.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Benzhydryl Compounds / urine*
  • Child
  • Child, Preschool
  • Cholesterol, HDL / blood
  • Dyslipidemias
  • Endocrine Disruptors / blood*
  • Female
  • Humans
  • Lipids / blood*
  • Male
  • Phenols / urine*
  • Triglycerides / blood


  • Benzhydryl Compounds
  • Cholesterol, HDL
  • Endocrine Disruptors
  • Lipids
  • Phenols
  • Triglycerides
  • bisphenol A