Purpose: Psoriasis is a chronic inflammatory skin disease that frequently debuts in childhood and adolescence. We wished to determine environmental and genetic risk factors for the development of psoriasis in children and adolescents, as well as to investigate debut type, trigger factors, course of disease, nature and influence of stress related to both child and family and risk factors for comorbidity. The 'Psoriasis in Adolescents' (PIA) cohort will provide data on the relationship between psoriasis and, respectively, genetic disposition, early-life exposures, quality of life and comorbidity.
Participants: The PIA cohort is nested in the large general population Danish National Birth Cohort (DNBC). We invited 390 adolescents with psoriasis and corresponding maternally predisposed and non-predisposed controls. Participants underwent an interview and a clinical examination consisting of a skin inspection and physical measurements including blood sampling and microbiological swabs. Additionally, four self-administered questionnaires on physical and mental health were completed.
Findings to date: The final PIA cohort consists of 81 adolescents with psoriasis, 110 parentally predisposed and 124 non-predisposed psoriasis-free adolescents. The validity of the maternally reported psoriasis status from the DNBC was found to be low on clinical examination (47.5%). In contrast, the self-reported psoriasis status of the DNBC mothers was clinically confirmed in 80.8% of the cases.
Future plans: The PIA cohort offers the possibility of assessing the clinical characteristics, course of psoriasis and development of comorbidities in adolescents with clinically confirmed disease from a general population. Comparison with predisposed and non-predisposed controls is possible and genetic analyses are scheduled. We plan to invite the participants for a follow-up in 5-10 years. Furthermore, we plan to include newly diagnosed adolescents with psoriasis from the 18-year DNBC follow-up. All information is linkable on the individual level with data from the DNBC and nationwide registries in Denmark.
Keywords: cardiovascular; comorbidity; genetics; metabolic; paediatric dermatology; psoriasis.
© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Conflict of interest statement
Competing interests: None declared.
Clinical Characteristics Including Cardiovascular and Metabolic Risk Factors in Adolescents With PsoriasisC Blegvad et al. J Eur Acad Dermatol Venereol. PMID 31989688.Overall, adolescents with psoriasis from this general population had mild disease. Still, early markers of cardiovascular and metabolic disease were elevated.
Cohort Profile: The Danish Future Occupation of Children and Adolescents Cohort (The FOCA Cohort): Education, Work-Life, Health and Living Conditions in a Life-Course PerspectiveL Lindholdt et al. BMJ Open 9 (2), e022784. PMID 30772844.The adolescents will be followed by ongoing linkage to administrative registers. Future studies will focus on factors affecting future health, education, work and well-be …
The Effect of Maternal Exposure to Psychosocial Job Strain on Pregnancy Outcomes and Child DevelopmentAD Larsen. Dan Med J 62 (2). PMID 25634513.Psychological stress at work is a rising problem in Denmark. Nearly one third of the women reported in 2005 that they had difficulties completing their work tasks, and 17 …
Childhood Depressive DisordersRT Wesselhoeft. Dan Med J 63 (10). PMID 27697136. - ReviewMajor depressive disorder (MDD) is a frequent and painful mental disorder considered among the five leading causes of disability in Western countries by the World Health …
Anti-TNF Agents for Paediatric PsoriasisG Sanclemente et al. Cochrane Database Syst Rev 2015 (11), CD010017. PMID 26598969. - ReviewThis review found only one RCT evaluating the use of this type of biological therapy. Although the risk of publication bias was high, as we included only one industry-spo …