Effects of accelerated versus standard care surgery on the risk of acute kidney injury in patients with a hip fracture: a substudy protocol of the hip fracture Accelerated surgical TreaTment And Care tracK (HIP ATTACK) international randomised controlled trial

doi:10.1136/bmjopen-2019-033150

. 2019 Sep 24;9(9):e033150.

doi: 10.1136/bmjopen-2019-033150.

Effects of accelerated versus standard care surgery on the risk of acute kidney injury in patients with a hip fracture: a substudy protocol of the hip fracture Accelerated surgical TreaTment And Care tracK (HIP ATTACK) international randomised controlled trial

Flavia K Borges^{1

2}, P J Devereaux^{2

3}, Meaghan Cuerden⁴, Mohit Bhandari⁵, Ernesto Guerra-Farfán⁶, Ameen Patel¹, Alben Sigamani⁷, Masood Umer⁸, John Neary¹, Maria Tiboni¹, Vikas Tandon¹, Mmampapatla Thomas Ramokgopa^{9

10}, Parag Sancheti¹¹, Bobby John¹², AbdelRahman Lawendy¹³, Mariano Balaguer-Castro¹⁴, Richard Jenkinson^{15

16}, Paweł Ślęczka¹⁷, Aamer Nabi Nur¹⁸, Gavin C A Wood¹⁹, Robert Feibel²⁰, John Stephen McMahon²¹, Alen Sigamani²², Bruce M Biccard²³, Giovanni Landoni^{24

25}, Wojciech Szczeklik²⁶, Chew Yin Wang²⁷, Jordi Tomas-Hernandez⁶, Valsa Abraham¹², Jessica Vincent², Valerie Harvey², Shirley Pettit², Jessica Sontrop²⁸, Amit X Garg^{29

4

28}; HIP ATTACK investigators

Affiliations

¹ Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
² Department of Perioperative Medicine, Population Health Research Institute, Hamilton, Ontario, Canada.
³ Departments of Health Research Methods, Evidence, and Impact (HEI), McMaster University, Hamilton, Ontario, Canada.
⁴ Division of Nephrology, Department of Medicine, Western University, London, Ontario, Canada.
⁵ Department of Surgery, McMaster University, Hamilton, Ontario, Canada.
⁶ Department of Orthopaedic Surgery and Traumatology, University Hospital Vall d'Hebron, Barcelona, Spain.
⁷ Clinical Research, Narayana Hrudayalaya Limited, Bangalore, India.
⁸ Department of Orthopaedic Surgery, Aga Khan University, Karachi, Pakistan.
⁹ Department of Orthopaedic Surgery, Chris Hani Baragwanath Academic Hospital, Johannesburg, South Africa.
¹⁰ Department of Orthopaedic Surgery, University of the Witwatersrand, Johannesburg, South Africa.
¹¹ Department of Orthopaedic Surgery, Sancheti Institute for Orthopaedics & Rehabilitation, Pune, India.
¹² Department of Orthopaedic Surgery, Christian Medical College and Hospital Ludhiana, Ludhiana, India.
¹³ Department of Surgery, Western University, London, Ontario, Canada.
¹⁴ Department of Orthopaedic Surgery and Traumatology, Parc Taulí Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí I3PT, Universitat Autònoma de Barcelona, Sabadell, Spain.
¹⁵ Department of Surgery and Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.
¹⁶ Department of Surgery, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
¹⁷ Orthopaedic Department, SPZOZ, Myslenice, Poland.
¹⁸ Department of Orthopaedic Surgery, Shifa International Hospital, Islamabad, Pakistan.
¹⁹ Department of Surgery, Queen's University, Kingston, Ontario, Canada.
²⁰ Division of Orthopaedic Surgery, Department of Surgery, University of Ottawa, Ottawa, Ontario, Canada.
²¹ Department of Surgery, Markham Stouffville Hospital, Markham, Ontario, Canada.
²² Department of Orthopaedic, Government TD Medical College, Allapuzha, India.
²³ Department of Anaesthesia and Perioperative Medicine, University of Cape Town, Rondebosch, South Africa.
²⁴ Department of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
²⁵ Department of Anaesthesia and Intensive Care, Vita-Salute San Raffaele University, Milan, Italy.
²⁶ Department of Intensive Care and Perioperative Medicine, Jagiellonian University Medical College, Krakow, Poland.
²⁷ Department of Anaesthesiology, University Malaya, Kuala Lumpur, Malaysia.
²⁸ Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada.
²⁹ Departments of Health Research Methods, Evidence, and Impact (HEI), McMaster University, Hamilton, Ontario, Canada amit.garg@lhsc.on.ca.

PMID: 31551393
PMCID: PMC6773307
DOI: 10.1136/bmjopen-2019-033150

Effects of accelerated versus standard care surgery on the risk of acute kidney injury in patients with a hip fracture: a substudy protocol of the hip fracture Accelerated surgical TreaTment And Care tracK (HIP ATTACK) international randomised controlled trial

Flavia K Borges et al. BMJ Open. 2019.

. 2019 Sep 24;9(9):e033150.

doi: 10.1136/bmjopen-2019-033150.

Authors

Affiliations

¹ Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
² Department of Perioperative Medicine, Population Health Research Institute, Hamilton, Ontario, Canada.
³ Departments of Health Research Methods, Evidence, and Impact (HEI), McMaster University, Hamilton, Ontario, Canada.
⁴ Division of Nephrology, Department of Medicine, Western University, London, Ontario, Canada.
⁵ Department of Surgery, McMaster University, Hamilton, Ontario, Canada.
⁶ Department of Orthopaedic Surgery and Traumatology, University Hospital Vall d'Hebron, Barcelona, Spain.
⁷ Clinical Research, Narayana Hrudayalaya Limited, Bangalore, India.
⁸ Department of Orthopaedic Surgery, Aga Khan University, Karachi, Pakistan.
⁹ Department of Orthopaedic Surgery, Chris Hani Baragwanath Academic Hospital, Johannesburg, South Africa.
¹⁰ Department of Orthopaedic Surgery, University of the Witwatersrand, Johannesburg, South Africa.
¹¹ Department of Orthopaedic Surgery, Sancheti Institute for Orthopaedics & Rehabilitation, Pune, India.
¹² Department of Orthopaedic Surgery, Christian Medical College and Hospital Ludhiana, Ludhiana, India.
¹³ Department of Surgery, Western University, London, Ontario, Canada.
¹⁴ Department of Orthopaedic Surgery and Traumatology, Parc Taulí Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí I3PT, Universitat Autònoma de Barcelona, Sabadell, Spain.
¹⁵ Department of Surgery and Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.
¹⁶ Department of Surgery, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
¹⁷ Orthopaedic Department, SPZOZ, Myslenice, Poland.
¹⁸ Department of Orthopaedic Surgery, Shifa International Hospital, Islamabad, Pakistan.
¹⁹ Department of Surgery, Queen's University, Kingston, Ontario, Canada.
²⁰ Division of Orthopaedic Surgery, Department of Surgery, University of Ottawa, Ottawa, Ontario, Canada.
²¹ Department of Surgery, Markham Stouffville Hospital, Markham, Ontario, Canada.
²² Department of Orthopaedic, Government TD Medical College, Allapuzha, India.
²³ Department of Anaesthesia and Perioperative Medicine, University of Cape Town, Rondebosch, South Africa.
²⁴ Department of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
²⁵ Department of Anaesthesia and Intensive Care, Vita-Salute San Raffaele University, Milan, Italy.
²⁶ Department of Intensive Care and Perioperative Medicine, Jagiellonian University Medical College, Krakow, Poland.
²⁷ Department of Anaesthesiology, University Malaya, Kuala Lumpur, Malaysia.
²⁸ Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada.
²⁹ Departments of Health Research Methods, Evidence, and Impact (HEI), McMaster University, Hamilton, Ontario, Canada amit.garg@lhsc.on.ca.

PMID: 31551393
PMCID: PMC6773307
DOI: 10.1136/bmjopen-2019-033150

Abstract

Introduction: Inflammation, dehydration, hypotension and bleeding may all contribute to the development of acute kidney injury (AKI). Accelerated surgery after a hip fracture can decrease the exposure time to such contributors and may reduce the risk of AKI.

Methods and analysis: Hip fracture Accelerated surgical TreaTment And Care tracK (HIP ATTACK) is a multicentre, international, parallel-group randomised controlled trial (RCT). Patients who suffer a hip fracture are randomly allocated to either accelerated medical assessment and surgical repair with a goal of surgery within 6 hours of diagnosis or standard care where a repair typically occurs 24 to 48 hours after diagnosis. The primary outcome of this substudy is the development of AKI within 7 days of randomisation. We anticipate at least 1998 patients will participate in this substudy.

Ethics and dissemination: We obtained ethics approval for additional serum creatinine recordings in consecutive patients enrolled at 70 participating centres. All patients provide consent before randomisation. We anticipate reporting substudy results by 2021.

Trial registration number: NCT02027896; Pre-results.

Keywords: accelerated surgery; acute kidney injury; hip fracture.

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Conflict of interest statement

Competing interests: None declared.

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Perazzo P, Giorgino R, Briguglio M, Zuffada M, Accetta R, Mangiavini L, Peretti GM. Perazzo P, et al. Front Med (Lausanne). 2020 Oct 15;7:566770. doi: 10.3389/fmed.2020.566770. eCollection 2020. Front Med (Lausanne). 2020. PMID: 33178713 Free PMC article.

References

1. Leslie WD. Trends in hip fracture rates in Canada. JAMA 2009;302 10.1001/jama.2009.1231 - DOI - PubMed
1. Woolf AD, Pfleger B. Burden of major musculoskeletal conditions. Bull World Health Organ 2003;81:646–56. - PMC - PubMed
1. The Hip Fracture Accelerated Surgical Treatment and Care Track (HIP ATTACK) Investigators Accelerated care versus standard care among patients with hip fracture: the hip attack pilot trial. Can Med Assoc J 2014;186:E52–60. 10.1503/cmaj.130901 - DOI - PMC - PubMed
1. Simunovic N, Devereaux PJ, Sprague S, et al. . Effect of early surgery after hip fracture on mortality and complications: systematic review and meta-analysis. Can Med Assoc J 2010;182:1609–16. 10.1503/cmaj.092220 - DOI - PMC - PubMed
1. Klestil T, Röder C, Stotter C, et al. . Impact of timing of surgery in elderly hip fracture patients: a systematic review and meta-analysis. Sci Rep 2018;8:13933 10.1038/s41598-018-32098-7 - DOI - PMC - PubMed

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[1] Leslie WD. Trends in hip fracture rates in Canada. JAMA 2009;302 10.1001/jama.2009.1231 - DOI - PubMed

[2] Leslie WD. Trends in hip fracture rates in Canada. JAMA 2009;302 10.1001/jama.2009.1231 - DOI - PubMed

[3] Woolf AD, Pfleger B. Burden of major musculoskeletal conditions. Bull World Health Organ 2003;81:646–56. - PMC - PubMed

[4] Woolf AD, Pfleger B. Burden of major musculoskeletal conditions. Bull World Health Organ 2003;81:646–56. - PMC - PubMed

[5] The Hip Fracture Accelerated Surgical Treatment and Care Track (HIP ATTACK) Investigators Accelerated care versus standard care among patients with hip fracture: the hip attack pilot trial. Can Med Assoc J 2014;186:E52–60. 10.1503/cmaj.130901 - DOI - PMC - PubMed

[6] The Hip Fracture Accelerated Surgical Treatment and Care Track (HIP ATTACK) Investigators Accelerated care versus standard care among patients with hip fracture: the hip attack pilot trial. Can Med Assoc J 2014;186:E52–60. 10.1503/cmaj.130901 - DOI - PMC - PubMed

[7] Simunovic N, Devereaux PJ, Sprague S, et al. . Effect of early surgery after hip fracture on mortality and complications: systematic review and meta-analysis. Can Med Assoc J 2010;182:1609–16. 10.1503/cmaj.092220 - DOI - PMC - PubMed

[8] Simunovic N, Devereaux PJ, Sprague S, et al. . Effect of early surgery after hip fracture on mortality and complications: systematic review and meta-analysis. Can Med Assoc J 2010;182:1609–16. 10.1503/cmaj.092220 - DOI - PMC - PubMed

[9] Klestil T, Röder C, Stotter C, et al. . Impact of timing of surgery in elderly hip fracture patients: a systematic review and meta-analysis. Sci Rep 2018;8:13933 10.1038/s41598-018-32098-7 - DOI - PMC - PubMed

[10] Klestil T, Röder C, Stotter C, et al. . Impact of timing of surgery in elderly hip fracture patients: a systematic review and meta-analysis. Sci Rep 2018;8:13933 10.1038/s41598-018-32098-7 - DOI - PMC - PubMed

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Effects of accelerated versus standard care surgery on the risk of acute kidney injury in patients with a hip fracture: a substudy protocol of the hip fracture Accelerated surgical TreaTment And Care tracK (HIP ATTACK) international randomised controlled trial

Affiliations

Effects of accelerated versus standard care surgery on the risk of acute kidney injury in patients with a hip fracture: a substudy protocol of the hip fracture Accelerated surgical TreaTment And Care tracK (HIP ATTACK) international randomised controlled trial

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