New Perspective for Non-invasive Brain Stimulation Site Selection in Mild Cognitive Impairment: Based on Meta- and Functional Connectivity Analyses

Jiao Liu; Binlong Zhang; Georgia Wilson; Jian Kong; Alzheimer’s Disease Neuroimaging Initiative

doi:10.3389/fnagi.2019.00228

New Perspective for Non-invasive Brain Stimulation Site Selection in Mild Cognitive Impairment: Based on Meta- and Functional Connectivity Analyses

Front Aging Neurosci. 2019 Aug 27:11:228. doi: 10.3389/fnagi.2019.00228. eCollection 2019.

Authors

Jiao Liu^{1

2}, Binlong Zhang^{1

2}, Georgia Wilson^{1

2}, Jian Kong^{1

2}; Alzheimer’s Disease Neuroimaging Initiative

Collaborators

Alzheimer’s Disease Neuroimaging Initiative:
Michael W Weiner, Paul Aisen, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R Jack Jr, William Jagust, John Q Trojanowki, Arthur W Toga, Laurel Beckett, Robert C Green, Andrew J Saykin, John Morris, Leslie M Shaw, Zaven Khachaturian, Greg Sorensen, Maria Carrillo, Lew Kuller, Marc Raichle, Steven Paul, Peter Davies, Howard Fillit, Franz Hefti, David Holtzman, M Marcel Mesulam, William Potter, Peter Snyder, Adam Schwartz, Robert C Green, Tom Montine, Ronald Petersen, Paul Aisen, Ronald G Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Archana B Balasubramanian, Jennifer Mason, Iris Sim, Laurel Beckett, Danielle Harvey, Michael Donohue, Clifford R Jack Jr, Matthew Bernstein, Nick Fox, Paul Thompson, Norbert Schuff, Charles DeCArli, Bret Borowski, Jeff Gunter, Matt Senjem, Prashanthi Vemuri, David Jones, Kejal Kantarci, Chad Ward, William Jagust, Robert A Koeppe, Norm Foster, Eric M Reiman, Kewei Chen, Chet Mathis, Susan Landau, John C Morris, Nigel J Cairns, Erin Franklin, Lisa Taylor-Reinwald, Leslie M Shaw, John Q Trojanowki, Virginia Lee, Magdalena Korecka, Michal Figurski, Arthur W Toga, Karen Crawford, Scott Neu, Andrew J Saykin, Tatiana M Foroud, Steven Potkin, Li Shen, Kelley Faber, Sungeun Kim, Kwangsik Nho, Michael W Weiner, Lean Thal, Zaven Khachaturian, Leon Thal, Neil Buckholtz, Michael W Weiner, Peter J Snyder, William Potter, Steven Paul, Marilyn Albert, Richard Frank, Zaven Khachaturian, John Hsiao, Jeffrey Kaye, Joseph Quinn, Lisa Silbert, Betty Lind, Raina Carter, Sara Dolen, Lon S Schneider, Sonia Pawluczyk, Mauricio Becerra, Liberty Teodoro, Bryan M Spann, James Brewer, Helen Vanderswag, Adam Fleisher, Judith L Heidebrink, Joanne L Lord, Ronald Petersen, Sara S Mason, Colleen S Albers, David Knopman, Kris Johnson, Rachelle S Doody, Javier Villanueva-Meyer, Valory Pavlik, Victoria Shibley, Munir Chowdhury, Susan Rountree, Mimi Dang, Yaakov Stern, Lawrence S Honig, Karen L Bell, Beau Ances, John C Morris, Maria Carroll, Mary L Creech, Erin Franklin, Mark A Mintun, Stacy Schneider, Angela Oliver, Daniel Marson, David Geldmacher, Marissa Natelson Love, Randall Griffith, David Clark, John Brockington, Erik Roberson, Hillel Grossman, Effie Mitsis, Raj C Shah, Leyla deToledo-Morrell, Ranjan Duara, Maria T Greig-Custo, Warren Barker, Marilyn Albert, Chiadi Onyike, Daniel D'Agostino 2nd, Stephanie Kielb, Martin Sadowski, Mohammed O Sheikh, Ulysse Anaztasia, Gaikwad Mrunalini, P Murali Doraiswamy, Jeffrey R Petrella, Salvador Borges-Neto, Terence Z Wong, Edward Coleman, Steven E Arnold, Jason H Karlawish, David A Wolk, Christopher M Clark, Charles D Smith, Greg Jicha, Peter Hardy, Partha Sinha, Elizabeth Oates, Gary Conrad, Oscar L Lopez, MaryAnn Oakley, Donna M Simpson, Anton P Porsteinsson, Bonnie S Goldstein, Kim Martin, Kelly M Makino, M Saleem Ismail, Connie Brand, Steven G Potkin, Adrian Preda, Dana Nguyen, Kyle Womack, Dana Mathews, Mary Quiceno, Allan I Levey, James J Lah, Janet S Cellar, Jeffrey M Burns, Russell H Swerdlow, William M Brooks, Liana Apostolova, Kathleen Tingus, Ellen Woo, Daniel Hs Silverman, Po H Lu, George Bartzokis, Neill R Graff-Radford, Francine Parfitt, Kim Poki-Walker, Martin R Farlow, Ann Marie Hake, Brandy R Matthews, Jared R Brosch, Scott Herring, Christopher H van Dyck, Richard E Carson, Martha G MacAvoy, Pradeep Varma, Howard Chertkow, Howard Bergman, Chris Hosein, Sandra Black, Bojana Stefanovic, Curtis Caldwell, Ging-Yuek Robin Hsiung, Benita Mudge, Vesna Sossi, Howard Feldman, Michele Assaly, Elizabeth Finger, Stephen Pasternack, Irina Rachisky, Dick Trost, Andrew Kertesz, Charles Bernick, Donna Munic, Marek-Marsel Mesulam, Emily Rogalski, Kristine Lipowski, Sandra Weintraub, Borna Bonakdarpour, Diana Kerwin, Chuang-Kuo Wu, Nancy Johnson, Carl Sadowsky, Teresa Villena, Raymond Scott Turner, Kathleen Johnson, Brigid Reynolds, Reisa A Sperling, Keith A Johnson, Gad Marshall, Jerome Yesavage, Joy L Taylor, Barton Lane, Allyson Rosen, Jared Tinklenberg, Marwan N Sabbagh, Christine M Belden, Sandra A Jacobson, Sherye A Sirrel, Neil Kowall, Ronald Killiany, Andrew E Budson, Alexander Norbash, Patricia Lynn Johnson, Thomas O Obisesan, Saba Wolday, Joanne Allard, Alan Lerner, Paula Ogrocki, Curtis Tatsuoka, Parianne Fatica, Evan Fletcher, Pauline Maillard, John Olichney, Charles DeCarli, Owen Carmichael, Smita Kittur, Michael Borrie, T-Y Lee, Rob Bartha, Sterling Johnson, Sanjay Asthana, Cynthia M Carlsson, Steven G Potkin, Adrian Preda, Dana Nguyen, Pierre Tariot, Anna Burke, Ann Marie Milliken, Nadira Trncic, Adam Fleisher, Stephanie Reeder, Vernice Bates, Horacio Capote, Michelle Rainka, Douglas W Scharre, Maria Kataki, Brendan Kelley, Earl A Zimmerman, Dzintra Celmins, Alice D Brown, Godfrey D Pearlson, Karen Blank, Karen Anderson, Laura A Flashman, Marc Seltzer, Mary L Hynes, Robert B Santulli, Kaycee M Sink, Gordineer Leslie, Jeff D Williamson, Pradeep Garg, Franklin Watkins, Brian R Ott, Geoffrey Tremont, Lori A Daiello, Stephen Salloway, Paul Malloy, Stephen Correia, Howard J Rosen, Bruce L Miller, David Perry, Jacobo Mintzer, Kenneth Spicer, David Bachman, Elizabeth Finger, Stephen Pasternak, Irina Rachinsky, John Rogers, Andrew Kertesz, Dick Drost, Nunzio Pomara, Raymundo Hernando, Antero Sarrael, Susan K Schultz, Karen Ekstam Smith, Hristina Koleva, Ki Won Nam, Hyungsub Shim, Norman Relkin, Gloria Chiang, Michael Lin, Lisa Ravdin, Amanda Smith, Balebail Ashok Raj, Kristin Fargher, Michael W Weiner, Paul Aisen, Michael Weiner, Paul Aisen, Ronald Petersen, Robert C Green, Danielle Harvey, Clifford R Jack Jr, William Jagust, John C Morris, Andrew J Saykin, Leslie M Shaw, Arthur W Toga, John Q Trojanowki, Thomas Neylan, Jordan Grafman, Robert C Green, Tom Montine, Michael Weiner, Ronald Petersen, Paul Aisen, Ronald G Thomas, Michael Donohue, Gessert Devon, Tamie Sather, Davis Melissa, Rosemary Morrison, Gus Jiminez, Thomas Neylan, Hayes Jacqueline, Finley Shannon, Danielle Harvey, Michael Donohue, Clifford R Jack Jr, Matthew Bernstein, Bret Borowski, Jeff Gunter, Matt Senjem, Kantarci Kejal, Ward Chad, William Jagust, Robert A Koeppe, Norm Foster, Eric M Reiman, Kewei Chen, Susan Landau, John C Morris, Nigel J Cairns, Erin Householder, Leslie M Shaw, John Q Trojanowki, Virginia Lee, Magdalena Korecka, Michal Figurski, Arthur W Toga, Crawford Karen, Neu Scott, Andrew J Saykin, Tatiana M Foroud, Steven Potkin, Li Shen, Kelley Faber, Sungeun Kim, Kwangsik Nho, Michael W Weiner, Friedl Karl, Lon S Schneider, Sonia Pawluczyk, Becerra Mauricio, James Brewer, Helen Vanderswag, Yaakov Stern, Lawrence S Honig, Karen L Bell, Debra Fleischman, Konstantinos Arfanakis, Raj C Shah, Ranjan Duara, Daniel Varon, Maria T Greig, P Murali Doraiswamy, Jeffrey R Petrella, Olga James, Anton P Porsteinsson, Bonnie Goldstein, Kimberly S Martin, Steven G Potkin, Adrian Preda, Dana Nguyen, Jacobo Mintzer, Dino Massoglia, Olga Brawman-Mintzer, Carl Sadowsky, Walter Martinez, Teresa Villena, William Jagust, Susan Landau, Howard Rosen, David Perry, Raymond Scott Turner, Kelly Behan, Brigid Reynolds, Reisa A Sperling, Keith A Johnson, Gad Marshall, Marwan N Sabbagh, Sandra A Jacobson, Sherye A Sirrel, Thomas O Obisesan, Saba Wolday, Joanne Allard, Sterling C Johnson, J Jay Fruehling, Sandra Harding, Elaine R Peskind, Eric C Petrie, Gail Li, Jerome A Yesavage, Joy L Taylor, Ansgar J Furst, Steven Chao, Norman Relkin, Gloria Chiang, Lisa Ravdin, Lisa Ravdin

Affiliations

¹ Author Affiliations: UC San Francisco; University of Southern California; UC San Francisco University of Southern California Mayo Clinic, Rochester Mayo Clinic, Rochester; UC Berkeley; U Pennsylvania; USC; UC Davis; Brigham and Women's Hospital/Harvard Medical School Indiana University Washington University St. Louis University of Pennsylvania; Prevent Alzheimer's Disease 2020 (Chair) Siemens; Alzheimer's Association University of Pittsburgh Washington University St. Louis Cornell University; Albert Einstein College of Medicine of Yeshiva University; AD Drug Discovery Foundation; Acumen Pharmaceuticals; Washington University St. Louis; Northwestern University; National Institute of Mental Health; Brown University; Eli Lilly (Chair); BWH/HMS (Chair); University of Washington (Chair); Mayo Clinic, Rochester (Core PI) University of Southern California; UC San Diego; UC San Diego; UC San Diego; UC San Diego; UC San Diego; UC San Diego; UC San Diego; UC San Diego; UC San Diego; UC Davis (Core PI); UC Davis; UC San Diego; Mayo Clinic, Rochester (Core PI); Mayo Clinic, Rochester; University of London; UCLA School of Medicine; UCSF MRI; UC Davis; Mayo Clinic; Mayo Clinic; Mayo Clinic; Mayo Clinic; Mayo Clinic; Mayo Clinic; Mayo Clinic; UC Berkeley (Core PI); University of Michigan; University of Utah; Banner Alzheimer's Institute; Banner Alzheimer's Institute; University of Pittsburgh; UC Berkeley; Washington University St. Louis; Washington University St. Louis; Washington University St. Louis; Washington University St. Louis; UPenn School of Medicine; UPenn School of Medicine; UPenn School of Medicine; UPenn School of Medicine; UPenn School of Medicine; USC (Core PI); USC; USC; Indiana University; Indiana University; UC Irvine; Indiana University; Indiana University; Indiana University; Indiana University; UC San Francisco; UC San Diego; Prevent Alzheimer's Disease 2020; UC San Diego; National Institute on Aging; UC San Francisco; Brown University; National Institute of Mental Health; Cornell University; Johns Hopkins University; Richard Frank Consulting; Prevent Alzheimer's Disease 2020; National Institute on Aging; Oregon Health & Science University; University of Southern California; University of California - San Diego; University of Michigan; Mayo Clinic, Rochester; Baylor College of Medicine; Columbia University Medical Center; Washington University, St. Louis; University of Alabama - Birmingham; Mount Sinai School of Medicine; Rush University Medical Center; Wien Center; Johns Hopkins University; New York University; Duke University Medical Center; University of Pennsylvania; University of Kentucky; University of Pittsburgh; University of Rochester Medical Center; University of California, Irvine; University of Texas Southwestern Medical School; Emory University; University of Kansas, Medical Center; University of California, Los Angeles; Mayo Clinic, Jacksonville; Indiana University; Yale University School of Medicine; McGill Univ., Montreal-Jewish General Hospital; Sunnybrook Health Sciences, Ontario; U.B.C. Clinic for AD & Related Disorders; Cognitive Neurology - St. Joseph's, Ontario; Cleveland Clinic Lou Ruvo Center for Brain Health; Northwestern University; Premiere Research Inst (Palm Beach Neurology); Georgetown University Medical Center; Brigham and Women's Hospital; Stanford University; Banner Sun Health Research Institute; Boston University; Howard University; Case Western Reserve University; University of California, Davis - Sacramento; Neurological Care of CNY; Parkwood Hospital; University of Wisconsin; University of California, Irvine - BIC; Banner Alzheimer's Institute; Dent Neurologic Institute; Ohio State University; Albany Medical College; Hartford Hospital, Olin Neuropsychiatry Research Center; Dartmouth-Hitchcock Medical Center; Wake Forest University Health Sciences; Rhode Island Hospital; Butler Hospital; UC San Francisco; Medical University South Carolina; St. Joseph's Health Care; Nathan Kline Institute; University of Iowa College of Medicine; Cornell University; University of South Florida: USF Health Byrd Alzheimer's Institute; University of California, San Francisco; University of Southern California; UC San Francisco; University of Southern California; Mayo Clinic, Rochester; Brigham and Women's Hospital/ Harvard Medical School; UC Davis; Mayo Clinic, Rochester; UC Berkeley; Washington University St. Louis; Indiana University; Perelman School of Medicine, UPenn; USC; Perelman School of Medicine, University of Pennsylvania; UC San Francisco; Rehabilitation Institute of Chicago, Feinberg School of Medicine, Northwestern University; BWH/HMS (Chair); University of Washington (Chair); Core PI; Mayo Clinic, Rochester (Core PI); University of Southern California; UC San Diego; UC San Diego; UC San Diego; UC San Diego; UC San Diego; UC San Diego; UC San Diego; UC San Francisco; UC San Francisco; UC San Francisco; UC Davis (Core PI); UC San Diego; Mayo Clinic, Rochester (Core PI); Mayo Clinic, Rochester; Mayo Clinic; Mayo Clinic; Mayo Clinic; Mayo Clinic; Mayo Clinic; UC Berkeley (Core PI); University of Michigan; University of Utah; Banner Alzheimer's Institute; Banner Alzheimer's Institute; UC Berkeley; Washington University St. Louis; Washington University St. Louis; Washington University St. Louis; Perelman School of Medicine, UPenn; Perelman School of Medicine, UPenn; Perelman School of Medicine, UPenn; Perelman School of Medicine, UPenn; Perelman School of Medicine, UPenn; USC (Core PI); USC; USC; Indiana University; Indiana University; UC Irvine; Indiana University; Indiana University; Indiana University; Indiana University; UC San Francisco; Department of Defense (retired); University of Southern California; University of California, San Diego; Columbia University Medical Center; Rush University Medical Center; Wien Center; Duke University Medical Center; University of Rochester Medical Center; University of California, Irvine; Medical University South Carolina; Premiere Research Inst (Palm Beach Neurology); University of California, San Francisco; Georgetown University Medical Center; Brigham and Women's Hospital; Banner Sun Health Research Institute; Howard University; University of Wisconsin; University of Washington; Stanford University; Cornell University.
² Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, MA, United States.

Abstract

Background: Non-invasive brain stimulation (NIBS) has been widely used to treat mild cognitive impairment (MCI). However, there exists no consensus on the best stimulation sites.

Objective: To explore potential stimulation locations for NIBS treatment in patients with MCI, combining meta- and resting state functional connectivity (rsFC) analyses.

Methods: The meta-analysis was conducted to identify brain regions associated with MCI. Regions of interest (ROIs) were extracted based on this meta-analysis. The rsFC analysis was applied to 45 MCI patients to determine brain surface regions that are functionally connected with the above ROIs.

Results: We found that the dorsolateral prefrontal cortex (DLPFC) and inferior frontal gyrus (IFG) were the overlapping brain regions between our results and those of previous studies. In addition, we recommend that the temporoparietal junction (including the angular gyrus), which was found in both the meta- and rsFC analysis, should be considered in NIBS treatment of MCI. Furthermore, the bilateral orbital prefrontal gyrus, inferior temporal gyrus, medial superior frontal gyrus, and right inferior occipital gyrus may be potential brain stimulation sites for NIBS treatment of MCI.

Conclusion: Our results provide several potential sites for NIBS, such as the DLFPC and IFG, and may shed light on the locations of NIBS sites in the treatment of patients with MCI.

Keywords: meta-analysis; mild cognitive impairment; non-invasive brain stimulation; resting state functional connectivity; stimulation site.

Abstract

Grants and funding