Declines in Lung Function After Antiretroviral Therapy Initiation in Adults With Human Immunodeficiency Virus and Tuberculosis: A Potential Manifestation of Respiratory Immune Reconstitution Inflammatory Syndrome

Sara C Auld; Pholo Maenetje; Shruthi Ravimohan; Drew Weissman; Itai Ncube; Mandla Mlotshwa; Nelly Ratsela; William Chase; Mboyo-Di-Tamba Vangu; Robert Wallis; Gavin Churchyard; Hardy Kornfeld; Gregory P Bisson

doi:10.1093/cid/ciz733

Declines in Lung Function After Antiretroviral Therapy Initiation in Adults With Human Immunodeficiency Virus and Tuberculosis: A Potential Manifestation of Respiratory Immune Reconstitution Inflammatory Syndrome

Clin Infect Dis. 2020 Apr 10;70(8):1750-1753. doi: 10.1093/cid/ciz733.

Authors

Affiliations

¹ School of Medicine and Rollins School of Public Health, Emory University, Atlanta, Georgia.
² Aurum Institute, Johannesburg, South Africa.
³ Department of Medicine, Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia.
⁴ Nuclear Medicine, CM Johannesburg Academic Hospital, University of the Witwatersrand, Johannesburg, South Africa.
⁵ Advancing Care and Treatment for TB/HIV, a Collaborating Centre of the South African Medical Research Council, Johannesburg, South Africa.
⁶ School of Public Health, University of the Witwatersrand, Johannesburg, South Africa.
⁷ Department of Medicine, University of Massachusetts Medical School, Worcester.
⁸ Department of Biostatistics, Epidemiology, and Informatics, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia.

Abstract

End-organ impairment has received relatively little research attention as a possible manifestation of tuberculosis immune reconstitution inflammatory syndrome (TB-IRIS). In this prospective cohort study, one-half of adults with human immunodeficiency virus and pulmonary tuberculosis experienced meaningful declines in lung function on antiretroviral therapy, suggesting a role for lung function in TB-IRIS definitions.

Keywords: HIV; immune reconstitution inflammatory syndrome; pulmonary function; tuberculosis.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Adult
HIV
HIV Infections* / complications
HIV Infections* / drug therapy
Humans
Immune Reconstitution Inflammatory Syndrome*
Lung
Prospective Studies
Tuberculosis*

Abstract

Publication types

MeSH terms

Grants and funding