Schisandrin A ameliorates MPTP-induced Parkinson's disease in a mouse model via regulation of brain autophagy

Arch Pharm Res. 2019 Nov;42(11):1012-1020. doi: 10.1007/s12272-019-01186-1. Epub 2019 Sep 24.


Schisandrin A (Sch A) is one of the principal bioactive lignans isolated from Fructus schisandrae. In this study, we demonstrated its protective effect and biochemical mechanism of action in a 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced mouse model of Parkinson's disease. Sch A significantly ameliorated behavioural abnormalities and increased the number of nigral dopaminergic neurons detected by tyrosine hydroxylase immunohistochemistry. Pre-treatment with Sch A significantly decreased the levels of the inflammatory mediators IL-6, IL-1β, and TNF-α and markedly improved antioxidant defences by inhibiting the activity of MDA and increasing that of SOD. Furthermore, Sch A activated expression of the autophagy-related proteins LC3-II, beclin1, parkin, and PINK1 and increased mTOR expression. Taken together, these findings indicate that Sch A has neuroprotective effects against the development of Parkinson's disease via regulation of brain autophagy.

Keywords: Autophagy; LC3-II; Parkinson’s disease; Schizandrin A.

MeSH terms

  • Animals
  • Autophagy / drug effects*
  • Autophagy-Related Proteins / immunology
  • Autophagy-Related Proteins / metabolism
  • Behavior, Animal / drug effects
  • Cyclooctanes / administration & dosage*
  • Disease Models, Animal
  • Dopaminergic Neurons / drug effects
  • Dopaminergic Neurons / immunology
  • Dopaminergic Neurons / pathology
  • Humans
  • Inflammation Mediators / immunology
  • Inflammation Mediators / metabolism
  • Lignans / administration & dosage*
  • MPTP Poisoning / drug therapy*
  • MPTP Poisoning / immunology
  • MPTP Poisoning / pathology
  • Male
  • Mice
  • Neuroprotective Agents / administration & dosage*
  • PC12 Cells
  • Polycyclic Compounds / administration & dosage*
  • Rats
  • Substantia Nigra / drug effects
  • Substantia Nigra / immunology*
  • Substantia Nigra / pathology


  • Autophagy-Related Proteins
  • Cyclooctanes
  • Inflammation Mediators
  • Lignans
  • Neuroprotective Agents
  • Polycyclic Compounds
  • schizandrin A