A case of monosomy-7 eosinophilic leukemia and neurofibromatosis, terminated with disseminated cryptococcosis

Korean J Intern Med. 1987 Jan;2(1):131-4. doi: 10.3904/kjim.1987.2.1.131.


A 17-year-old boy was admitted with fever, generalized lymphadenopathy, hepatosplenomegaly, multiple cāfe-au-lait spots, and a family history of neurofibromatosis. The peripheral blood showed anemia, leukocytosis with 9% blasts, 54% eosinophils of abnormal morphology, and thrombocytopenia. No cause for hypereosinophilia was found. Bone marrow aspiration revealed hypercellularity with 20% myeloblasts and 35% eosinophilic leukocytes. The cytogenetic analysis of bone marrow cells with G-banding techniques showed a karyotype of 45, XY, −7. Based upon these findings, the authors believed that the patient had eosinophilic leukemia and neurofibromatosis. The patient rapidly declined and died from disseminated cryptococcosis.

This case provided additional evidence of a link between aneuploidy of the group C chromosome and hematologic malignancy.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Chromosomes, Human, Pair 7*
  • Cryptococcosis / complications
  • Humans
  • Leukemia, Eosinophilic, Acute / complications*
  • Leukemia, Eosinophilic, Acute / genetics
  • Male
  • Monosomy*
  • Neurofibromatosis 1 / complications*
  • Neurofibromatosis 1 / genetics