Bacillus coagulans GBI-30, 6068 decreases upper respiratory and gastrointestinal tract symptoms in healthy Mexican scholar-aged children by modulating immune-related proteins

Food Res Int. 2019 Nov;125:108567. doi: 10.1016/j.foodres.2019.108567. Epub 2019 Jul 21.


This randomized, double-blind, parallel and placebo-controlled study aimed to evaluate the effect of Bacillus coagulans GBI-30, 6086® probiotic (GanedenBC30®) against upper respiratory tract infections (URTI) and gastrointestinal tract infections (GITI) in eighty healthy school-aged children (6-8 years old). The participants received daily a sachet containing either GanedenBC30 (1 × 109 colony-forming units) or placebo (maltodextrin) for three months. GanedenBC30 significantly decreased the incidence of URTI symptoms including nasal congestion, bloody nasal mucus, itchy nose, and hoarseness. The duration of the URTI-associated symptoms of hoarseness, headache, red eyes, and fatigue was also decreased. GanedenBC30 supplementation also significantly reduced the incidence rate of flatulence. These beneficial effects were associated with the modulation of serum TNFα, CD163, G-CSF, ICAM-1, IL-6, IL-8, MCP-2, RAGE, uPAR, and PF4. Therefore, probiotic B. coagulans GBI-30, 6086 modulated immune-related proteins in healthy children, decreasing several URTI and GITI symptoms, thus, this functional ingredient may contribute to a healthier lifestyle.

Keywords: Bacillus coagulans GBI-30; GanedenBC(30)®; Gastrointestinal; Immune system; Probiotic; Upper respiratory.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacillus coagulans / immunology*
  • Child
  • Double-Blind Method
  • Female
  • Gastrointestinal Diseases / epidemiology*
  • Gastrointestinal Diseases / immunology
  • Gastrointestinal Diseases / prevention & control*
  • Gastrointestinal Tract / drug effects
  • Gastrointestinal Tract / immunology
  • Humans
  • Incidence
  • Male
  • Mexico / epidemiology
  • Probiotics / pharmacology*
  • Respiratory System / drug effects
  • Respiratory System / immunology
  • Respiratory Tract Infections / epidemiology*
  • Respiratory Tract Infections / immunology
  • Respiratory Tract Infections / prevention & control*
  • Severity of Illness Index
  • Time