Serological response to syphilis treatment. A new analysis of old data

JAMA. 1985 Mar 1;253(9):1296-9.


One important aspect of the posttreatment evaluation of patients with early syphilis is assessment of serological test results. Using information previously collected from 818 patients in the Early Syphilis Study, we evaluated the seroresponse of people treated for primary or secondary syphilis. We generated curves describing the VDRL titer declines with time. The VDRL titer declined approximately fourfold at three months and eightfold at six months. These observations will allow clinicians to identify treatment failures or reinfections at the earliest possible time during their follow-up.

MeSH terms

  • Antibodies, Bacterial / analysis
  • Drug Therapy, Combination
  • Erythromycin / therapeutic use
  • Humans
  • Models, Theoretical
  • Penicillins / therapeutic use
  • Recurrence
  • Spectinomycin / therapeutic use
  • Syphilis / drug therapy*
  • Syphilis / immunology
  • Syphilis Serodiagnosis* / methods
  • Tetracycline / therapeutic use
  • Time Factors


  • Antibodies, Bacterial
  • Penicillins
  • Erythromycin
  • Spectinomycin
  • Tetracycline