Visualising three-dimensional genome organisation in two dimensions

Development. 2019 Sep 26;146(19):dev177162. doi: 10.1242/dev.177162.


The three-dimensional organisation of the genome plays a crucial role in developmental gene regulation. In recent years, techniques to investigate this organisation have become more accessible to labs worldwide due to improvements in protocols and decreases in the cost of high-throughput sequencing. However, the resulting datasets are complex and can be challenging to analyse and interpret. Here, we provide a guide to visualisation approaches that can aid the interpretation of such datasets and the communication of biological results.

Keywords: Chromatin conformation; Data visualisation; Gene regulation; Genome organisation; Hi-C data.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Algorithms
  • Animals
  • Chromatin / genetics
  • Genome*
  • Humans
  • Imaging, Three-Dimensional*


  • Chromatin