On the use of the modified power series family of distributions in a cure rate model context

Stat Methods Med Res. 2020 Jul;29(7):1831-1845. doi: 10.1177/0962280219876962. Epub 2019 Sep 27.

Abstract

In this paper, we propose a generalization of the power series cure rate model for the number of competing causes related to the occurrence of the event of interest. The model includes distributions not yet used in the cure rate models context, such as the Borel, Haight and Restricted Generalized Poisson distributions. The model is conveniently parameterized in terms of the cure rate. Maximum likelihood estimation based on the Expectation Maximization algorithm is discussed. A simulation study designed to assess some properties of the estimators is carried out, showing the good performance of the proposed estimation procedure in finite samples. Finally, an application to a bone marrow transplant data set is presented.

Keywords: Expectation Maximization algorithm; long-term survival models; maximum likelihood; promotion time cure rate model; survival analysis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms*
  • Likelihood Functions
  • Models, Statistical*
  • Poisson Distribution
  • Survival Analysis