Migraine: Epidemiology, Burden, and Comorbidity

Neurol Clin. 2019 Nov;37(4):631-649. doi: 10.1016/j.ncl.2019.06.001. Epub 2019 Aug 27.


Migraine affects an estimated 12% of the population. Global estimates are higher. Chronic migraine (CM) affects 1% to 2% of the global population. Approximately 2.5% of persons with episodic migraine progress to CM. Several risk factors are associated with the progression to CM. There is significant short-term variability in migraine frequency independent of treatment. Migraine is associated with cardiovascular disease, psychiatric disease, and sleep disorders. It is the second most disabling condition worldwide. CM is associated with higher headache-related disability/impact, medical and psychiatric comorbidities, health care resource use, direct and indirect costs, lower socioeconomic status, and health-related quality of life.

Keywords: Chronic migraine (CM); Comorbidity; Headache-related disability; Incidence; Migraine; Prevalence; Progression; Risk factors.

Publication types

  • Review

MeSH terms

  • Cardiovascular Diseases / epidemiology
  • Cardiovascular Diseases / psychology
  • Cardiovascular Diseases / therapy
  • Chronic Disease
  • Comorbidity
  • Cost of Illness*
  • Disease Progression
  • Humans
  • Mental Disorders / epidemiology
  • Mental Disorders / psychology
  • Mental Disorders / therapy
  • Migraine Disorders / epidemiology*
  • Migraine Disorders / psychology*
  • Migraine Disorders / therapy
  • Quality of Life / psychology*
  • Risk Factors
  • Sleep Wake Disorders / epidemiology
  • Sleep Wake Disorders / psychology
  • Sleep Wake Disorders / therapy