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. 2020 Jan;158(2):368-388.
doi: 10.1053/j.gastro.2019.06.047. Epub 2019 Sep 26.

Chemoprevention of Colorectal Cancer

Free PMC article

Chemoprevention of Colorectal Cancer

Bryson W Katona et al. Gastroenterology. .
Free PMC article


Although colorectal cancer (CRC) screening has reduced the incidence of and mortality from CRC, chemoprevention strategies have the potential to further reduce CRC incidence and mortality. Chemoprevention agents might be used for average-risk as well as high-risk groups, and to prevent CRC recurrence after therapy. CRC chemoprevention agents that have been studied include aspirin, nonaspirin nonsteroidal anti-inflammatory drugs, statins, agents that target metabolic pathways, and vitamins and minerals. We review the prospect of chemoprevention of CRC, results from preclinical and human studies, challenges, and future directions.

Keywords: Adenoma; Chemoprevention; Colorectal Cancer.

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