Systems biology based drug repositioning for development of cancer therapy

Semin Cancer Biol. 2021 Jan;68:47-58. doi: 10.1016/j.semcancer.2019.09.020. Epub 2019 Sep 27.

Abstract

Drug repositioning is a powerful method that can assists the conventional drug discovery process by using existing drugs for treatment of a disease rather than its original indication. The first examples of repurposed drugs were discovered serendipitously, however data accumulated by high-throughput screenings and advancements in computational biology methods have paved the way for rational drug repositioning methods. As chemotherapeutic agents have notorious side effects that significantly reduce quality of life, drug repositioning promises repurposed noncancer drugs with little or tolerable adverse effects for cancer patients. Here, we review current drug-related data types and databases including some examples of web-based drug repositioning tools. Next, we describe systems biology approaches to be used in drug repositioning for effective cancer therapy. Finally, we highlight examples of mostly repurposed drugs for cancer treatment and provide an overview of future expectations in the field for development of effective treatment strategies.

Keywords: Cancer; Drug repositioning; Network-based approaches; Signature-based approaches; Systems biology.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / therapeutic use*
  • Computational Biology / methods*
  • Drug Discovery*
  • Drug Repositioning / methods*
  • Humans
  • Neoplasms / drug therapy*
  • Systems Biology / methods*

Substances

  • Antineoplastic Agents