Biogenesis and ceRNA role of circular RNAs in skeletal muscle myogenesis

Binglin Yue; Jian Wang; Chengchuang Song; Jiyao Wu; Xiukai Cao; Yongzheng Huang; Xianyong Lan; Chuzhao Lei; Bizhi Huang; Hong Chen

doi:10.1016/j.biocel.2019.105621

Biogenesis and ceRNA role of circular RNAs in skeletal muscle myogenesis

Int J Biochem Cell Biol. 2019 Dec:117:105621. doi: 10.1016/j.biocel.2019.105621. Epub 2019 Sep 27.

Authors

Affiliations

¹ College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, China.
² Yunnan Academy of Grassland and Animal Science, Kunming, Yunnan 650212, China.
³ College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, China. Electronic address: chenhong1212@263.net.

PMID: 31568883
DOI: 10.1016/j.biocel.2019.105621

Abstract

Circular RNAs (circRNAs) are novel endogenous non-coding RNAs that are generated by reverse-splicing of precursor mRNA derived from various genes in mammals. Despite low expression, recent studies have shown that circRNA plays an important role in skeletal muscle myogenesis with competing endogenous RNA (ceRNA) functions. However, the potential regulatory role of circRNAs and interactions with miRNAs remain largely unexplored, and the function of circRNAs as miRNA sponges is not yet generally accepted. In this review, we outline the biogenesis and ceRNA mechanisms of circRNAs as well as their involvement in skeletal muscle myogenesis and discuss the conflicting conclusions of recent circRNA-ceRNA studies.

Keywords: Skeletal muscle; ceRNA; circRNA.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Humans
Muscle Development / genetics*
Muscle, Skeletal / metabolism*
RNA / genetics*
RNA, Circular / genetics*

Substances

RNA, Circular
RNA