Amyloidosis secondary to chronic pulmonary aspergillosis: Case report and a systematic review of literature

J Mycol Med. 2019 Dec;29(4):372-374. doi: 10.1016/j.mycmed.2019.100898. Epub 2019 Sep 12.


Secondary amyloidosis results from the deposition of abnormally folded proteins in body organs due to chronic inflammatory disorders. Kidneys are the most commonly affected organ and manifest as nephrotic syndrome with or without renal failure. Chronic pulmonary aspergillosis (CPA) is a chronic infection of lung parenchyma affecting those with an underlying structural lung disease. Herein, we present a case of CPA where the initial manifestation was that of nephrotic syndrome due to renal amyloidosis. We also perform a systematic review for studies describing secondary amyloidosis due to CPA.

Keywords: Amyloidosis; Aspergillosis; CPA; Nephrotic syndrome; Renal failure.

Publication types

  • Case Reports
  • Systematic Review

MeSH terms

  • Adult
  • Amyloidosis / diagnosis*
  • Amyloidosis / microbiology*
  • Chronic Disease
  • Female
  • Humans
  • Kidney / microbiology
  • Kidney / pathology*
  • Nephrotic Syndrome / complications*
  • Pulmonary Aspergillosis / complications*