Amyloidosis secondary to chronic pulmonary aspergillosis: Case report and a systematic review of literature

D Patel; R Agarwal; S Dhooria; U Hedge; H Patel; I Singh Sehgal

doi:10.1016/j.mycmed.2019.100898

Amyloidosis secondary to chronic pulmonary aspergillosis: Case report and a systematic review of literature

J Mycol Med. 2019 Dec;29(4):372-374. doi: 10.1016/j.mycmed.2019.100898. Epub 2019 Sep 12.

Authors

D Patel¹, R Agarwal², S Dhooria², U Hedge³, H Patel³, I Singh Sehgal⁴

Affiliations

¹ City Clinic and Bhailal Amin General Hospital, Vadodara, Gujrat, India.
² Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
³ MPU Hospital, Nadiad, Gujrat, India.
⁴ Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Electronic address: inderpgi@outlook.com.

PMID: 31570305
DOI: 10.1016/j.mycmed.2019.100898

Abstract

Secondary amyloidosis results from the deposition of abnormally folded proteins in body organs due to chronic inflammatory disorders. Kidneys are the most commonly affected organ and manifest as nephrotic syndrome with or without renal failure. Chronic pulmonary aspergillosis (CPA) is a chronic infection of lung parenchyma affecting those with an underlying structural lung disease. Herein, we present a case of CPA where the initial manifestation was that of nephrotic syndrome due to renal amyloidosis. We also perform a systematic review for studies describing secondary amyloidosis due to CPA.

Keywords: Amyloidosis; Aspergillosis; CPA; Nephrotic syndrome; Renal failure.

Publication types

Case Reports
Systematic Review

MeSH terms

Adult
Amyloidosis / diagnosis*
Amyloidosis / microbiology*
Chronic Disease
Female
Humans
Kidney / microbiology
Kidney / pathology*
Nephrotic Syndrome / complications*
Pulmonary Aspergillosis / complications*