The Genetics and Mechanisms of T-Cell Acute Lymphoblastic Leukemia

Cold Spring Harb Perspect Med. 2020 Mar 2;10(3):a035246. doi: 10.1101/cshperspect.a035246.


T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy derived from early T-cell progenitors. The recognition of clinical, genetic, transcriptional, and biological heterogeneity in this disease has already translated into new prognostic biomarkers, improved leukemia animal models, and emerging targeted therapies. This work reviews our current understanding of the molecular mechanisms of T-ALL.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / therapeutic use
  • Biomarkers, Tumor / genetics*
  • Disease Models, Animal
  • Gene Expression Regulation, Leukemic
  • Humans
  • Mutation
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / metabolism
  • Receptor, Notch1 / antagonists & inhibitors*
  • Receptor, Notch1 / genetics*
  • Receptor, Notch1 / metabolism


  • Antineoplastic Agents
  • Biomarkers, Tumor
  • NOTCH1 protein, human
  • Receptor, Notch1