Subacute and chronic bone infections: diagnosis using In-111, Ga-67 and Tc-99m MDP bone scintigraphy, and radiography

Radiology. 1985 May;155(2):501-6. doi: 10.1148/radiology.155.2.3157204.


The usefulness of indium-111 white blood cell scintigraphy in the diagnosis of subacute or chronic bone infection was examined in 21 orthopedic patients. In-111 WBC imaging was compared with gallium-67 and technetium-99m methylene diphosphonate skeletal scintigraphy and bone radiography, all studies being performed within 1 week. In-111 WBC scintigraphy showed no definite advantage over Ga-67 scintigraphy in the identification of chronic bone infection. The two tests had the same sensitivity (80%) and similar specificity (In-111 WBC 75%, Ga-67 83%; difference not significant). Bone radiography had a sensitivity of 60% and a specificity of 67%. A negative Tc-99m MDP bone scintigram ruled out infection (sensitivity 100%), but because of low specificity (25%), final evaluation required performance of Ga-67 or In-111 WBC scintigraphy.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Bone Diseases / diagnostic imaging*
  • Bone Diseases / etiology
  • Chronic Disease
  • Diphosphonates*
  • Gallium Radioisotopes*
  • Humans
  • Indium*
  • Infections / diagnostic imaging*
  • Leukocytes
  • Middle Aged
  • Radiography
  • Radioisotopes*
  • Radionuclide Imaging
  • Technetium Tc 99m Medronate
  • Technetium*


  • Diphosphonates
  • Gallium Radioisotopes
  • Radioisotopes
  • Indium
  • Technetium
  • Technetium Tc 99m Medronate