IRE1 Signaling As a Putative Therapeutic Target in Influenza Virus-induced Pneumonia

Am J Respir Cell Mol Biol. 2019 Oct;61(4):537-540. doi: 10.1165/rcmb.2019-0123LE.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alveolar Epithelial Cells / drug effects*
  • Alveolar Epithelial Cells / enzymology
  • Animals
  • Apoptosis / drug effects
  • Cells, Cultured
  • Endoplasmic Reticulum Stress / drug effects
  • Endoribonucleases / antagonists & inhibitors*
  • Endoribonucleases / physiology
  • Gene Expression Regulation, Viral / drug effects
  • Humans
  • Hymecromone / analogs & derivatives
  • Influenza A Virus, H1N1 Subtype / genetics
  • Influenza A Virus, H1N1 Subtype / physiology
  • Influenza, Human / complications*
  • Influenza, Human / drug therapy
  • Mice
  • Mice, Inbred C57BL
  • Molecular Targeted Therapy*
  • Orthomyxoviridae Infections / complications*
  • Orthomyxoviridae Infections / drug therapy
  • Pneumonia, Viral / drug therapy*
  • Pneumonia, Viral / enzymology
  • Pneumonia, Viral / etiology
  • Protein-Serine-Threonine Kinases / antagonists & inhibitors*
  • Protein-Serine-Threonine Kinases / physiology
  • Salicylanilides / therapeutic use*
  • Transcription, Genetic
  • Unfolded Protein Response / drug effects
  • Viral Proteins / biosynthesis
  • Viral Proteins / genetics
  • Virus Replication / drug effects

Substances

  • 4-methylumbelliferone 8-carbaldehyde
  • Salicylanilides
  • Viral Proteins
  • Hymecromone
  • metabromsalan
  • ERN1 protein, human
  • Protein-Serine-Threonine Kinases
  • Endoribonucleases