Coxiella burnetii is an intracellular bacterium that causes acute and chronic Q fever. This unique pathogen has been historically challenging to study due to obstacles in genetically manipulating the organism and the inability of small animal models to fully mimic human Q fever. Here, we review the current state of C. burnetii research, highlighting new approaches that allow the mechanistic study of infection in disease relevant settings.
Keywords: Coxiella burnetii; Intracellular; Macrophage; Q fever.
Copyright © 2019 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.