Cancer Progress and Priorities: Lung Cancer

Cancer Epidemiol Biomarkers Prev. 2019 Oct;28(10):1563-1579. doi: 10.1158/1055-9965.EPI-19-0221.


In the United States, lung cancer is the second most common diagnosed cancer and the leading cause of cancer-related death. Though tobacco smoking is the major risk factor accounting for 80 to 90% of all lung cancer diagnoses, there are numerous other risk factors that have been identified as casually associated with lung cancer etiology. However, there are few causally-linked risk factors for lung cancer diagnosed among never smokers which, if considered a unique reportable category, is the 11th most common cancer and the 7th leading cause of cancer-related death. Lung cancer survival has only marginally improved over the last several decades, but the availability of screening and early detection by low-dose computer tomography and advances in targeted treatments and immunotherapy will likely decrease mortality rates and improve patient survival outcomes in the near future.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Early Detection of Cancer / methods
  • Early Detection of Cancer / mortality
  • Genomics / methods
  • Humans
  • Immunotherapy / methods
  • Lung Neoplasms / diagnosis*
  • Lung Neoplasms / epidemiology
  • Lung Neoplasms / mortality
  • Lung Neoplasms / therapy*
  • Molecular Targeted Therapy / methods
  • Prognosis
  • Risk Factors
  • Survival Rate
  • United States / epidemiology